Evidence map›Paper›PMID 39722888›Full record

ArticleACS catalysis2024

Characterization of VldE (Spr1875), a Pneumococcal Two-State l,d-Endopeptidase with a Four-Zinc Cluster in the Active Site.

Vega Miguel-Ruano, Iván Acebrón, Mijoon Lee, Antonio J Martín-Galiano, Celine Freton, Uxía P de José, Balajee Ramachandran, Federico Gago, Morten Kjos, Dusan Hesek and 5 more

Abstract read
In one paragraph

Article in ACS catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vega Miguel-RuanoDepartment of Crystallography and Structural Biology, Consejo Superior de Investigaciones Científicas, Instituto de Química-Física "Blas Cabrera", Madrid 28006, Spain.ORCID https://orcid.org/0000-0002-2492-7164
Iván AcebrónDepartment of Crystallography and Structural Biology, Consejo Superior de Investigaciones Científicas, Instituto de Química-Física "Blas Cabrera", Madrid 28006, Spain.
Mijoon LeeDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0001-7432-0427
Antonio J Martín-GalianoCore Scientific and Technical Units, Carlos III Health Institute, Majadahonda, Madrid 28222, Spain.ORCID https://orcid.org/0000-0002-6662-329X
Celine FretonMolecular Microbiology and Structural Biochemistry, CNRS UMR, Université de Lyon, Lyon 69367, France.ORCID https://orcid.org/0000-0003-2722-8171
Uxía P de JoséDepartment of Crystallography and Structural Biology, Consejo Superior de Investigaciones Científicas, Instituto de Química-Física "Blas Cabrera", Madrid 28006, Spain.
Balajee RamachandranDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Federico GagoDepartment of Biomedical Sciences and IQM-CSIC Associate Unit, School of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares 28805, Spain.ORCID https://orcid.org/0000-0002-3071-4878
Morten KjosDepartment of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1430, Norway.ORCID https://orcid.org/0000-0003-4448-9082
Dusan HesekDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Christophe GrangeasseMolecular Microbiology and Structural Biochemistry, CNRS UMR, Université de Lyon, Lyon 69367, France.ORCID https://orcid.org/0000-0002-5484-4589
Leiv Sigve HåvarsteinDepartment of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1430, Norway.
Daniel StraumeDepartment of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1430, Norway.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0002-7695-7883
Juan A HermosoDepartment of Crystallography and Structural Biology, Consejo Superior de Investigaciones Científicas, Instituto de Química-Física "Blas Cabrera", Madrid 28006, Spain.ORCID https://orcid.org/0000-0002-1862-8950

Funding

Cell-Wall Recycling and Nexus to Antibiotic ResistanceR35GM131685 · NIGMS · UNIVERSITY OF NOTRE DAME · PI MOBASHERY, SHAHRIAR · 2019 to 2023
$1.9M
NIGMS NIH HHS R35 GM131685
6 · The paper itself

Abstract

Remodeling of the pneumococcal cell wall, carried out by peptidoglycan (PG) hydrolases, is imperative for maintaining bacterial cell shape and ensuring survival, particularly during cell division or stress response. The

Identifiers

PMID39722888
PMCPMC11667670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.