ArticleFrontiers in medicine2024
The endothelial activation and stress index is a potential prognostic indicator for patients with acute pancreatitis managed in the intensive care unit: a retrospective study.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Association between the endothelial activation and stress index and 28-day all-cause mortality in critically ill patients with chronic obstructive pulmonary disease: a retrospective cohort study and predictive model establishment based on machine learning.BMC pulmonary medicine · 2026Article
- Association between the endothelial activation and stress index and 30-day in-hospital mortality rate in patients with traumatic lung injury: a retrospective analysis based on the MIMIC-IV database.Journal of thoracic disease · 2026Article
- Dynamic Assessment of Modified EASIX (m-EASIX) at 48 Hours Predicts Adverse Outcomes in Acute Pancreatitis: A Propensity Score-Matched Study.Medicina (Kaunas, Lithuania) · 2026Article
- The endothelial activation and stress index as a key prognostic marker in severe ischemic stroke.European journal of medical research · 2026Article
- Post-translational modification crosstalk in acute pancreatitis: linking acinar stress to innate immune amplification and tissue repair.Frontiers in immunology · 2026Review
- Predictive value of endothelial activation and stress index for acute kidney injury in hospitalized patients with multiple myeloma.American journal of translational research · 2026Article
- EASIX as a moderately effective prognostic marker for mortality in severe acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Article
- Endothelial activation and stress index predicts 28-day mortality in patients undergoing CRRT.Biomolecules & biomedicine · 2025Article
- Association of the endothelial activation and stress index with cognitive function in older adults: a cross-sectional study with machine learning.European journal of medical research · 2025Article
- The association between endothelial activation and stress Index and the development and prognosis of acute kidney injury in elderly patients with critical illness.Renal failure · 2025Article
- EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Endothelial activation and stress index and cardiovascular disease among American population-findings from NHANES 1999-2018.BMC cardiovascular disorders · 2025Article
- Association between the Endothelial Activation and Stress Index (EASIX) and all-cause and cardiovascular mortality in patients with diabetes and prediabetes.European journal of medical research · 2025Article
- Independent prognostic importance of endothelial activation and stress index (EASIX) in critically ill patients with heart failure: modulating role of inflammation.Frontiers in medicine · 2025Article
- Applying EASIX in Osteoarthritis. The Link between Inflammation and Cardiovascular Risk.Arquivos brasileiros de cardiologia · 2025Article
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6 authors.
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Abstract
Background: The endothelial activation and stress index (EASIX) serves as a dependable and efficient surrogate marker for endothelial dysfunction, which plays an essential role in the pathophysiology of acute pancreatitis (AP). Hence, we investigated the prognostic value of EASIX in AP. Methods: This was a retrospective study, using patient information obtained from the Medical Information Market for Intensive Care-IV (MIMIC-IV) database. EASIX was calculated using lactate dehydrogenase, serum creatinine, and platelet counts obtained during the first measurement within 24 h of admission. Patients were grouped into three cohorts based on log2-transformed EASIX. The main endpoint of the study was 28-day all-cause mortality (ACM) in AP patients, with the secondary endpoint being 90-day ACM. The relationship between EASIX and prognosis in patients with AP was evaluated using Cox proportional hazards models, Kaplan-Meier curves, restricted cubic spline (RCS) curves, and subgroup analyses. Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive performance of EASIX compared to other indicators. Results: The study cohort comprised 620 patients in total. Multivariate Cox proportional hazards analysis indicated that an increased log2 (EASIX) was linked to a higher risk of 28-day ACM in AP patients (HR, 1.32; 95% CI: 1.14-1.52; Conclusion: Elevated EASIX levels were significantly correlated with a heightened risk of 28- and 90-day ACM in AP patients.
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