Evidence map›Paper›PMID 39722752›Full record

ArticleWorld journal of virology2024

Diagnosis of West Nile virus infections: Evaluation of different laboratory methods.

Tatjana Vilibic-Cavlek, Maja Bogdanic, Vladimir Savic, Zeljka Hruskar, Ljubo Barbic, Vladimir Stevanovic, Ljiljana Antolasic, Ljiljana Milasincic, Dario Sabadi, Gorana Miletic and 4 more

Abstract read
In one paragraph

Article in World journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
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  4. A thousand faces of West Nile virus neuroinvasive disease: a consecutive case series in Southern Italy during summer 2025.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tatjana Vilibic-CavlekDepartment of Virology, Croatian Institute of Public Health, Zagreb 10000, Croatia.
Maja BogdanicDepartment of Virology, Croatian Institute of Public Health, Zagreb 10000, Croatia.
Vladimir SavicPoultry Center, Croatian Veterinary Institute, Zagreb 10000, Croatia.
Zeljka HruskarDepartment of Virology, Croatian Institute of Public Health, Zagreb 10000, Croatia.
Ljubo BarbicDepartment of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine University of Zagreb, Zagreb 10000, Croatia.
Vladimir StevanovicDepartment of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine University of Zagreb, Zagreb 10000, Croatia.
Ljiljana AntolasicDepartment of Virology, Croatian Institute of Public Health, Zagreb 10000, Croatia.
Ljiljana MilasincicDepartment of Virology, Croatian Institute of Public Health, Zagreb 10000, Croatia.
Dario SabadiDepartment of Infectious Diseases, Clinical Hospital Center Osijek, Osijek 31000, Croatia.
Gorana MileticDepartment of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine University of Zagreb, Zagreb 10000, Croatia.
Ivona CoricDepartment of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine University of Zagreb, Zagreb 10000, Croatia.
Anna MrzljakSchool of Medicine, University of Zagreb, Zagreb 10000, Croatia.
Eddy ListesCroatian Veterinary Institute, Veterinary Institute Split, Split 21000, Croatia.
Giovanni SaviniOIE Reference Center for West Nile Disease, Istituto Zooprofilattico Sperimentale, G. Caporale, Teramo 64100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diagnosis of West Nile virus (WNV) is challenging due to short-term and low-level viremia, flavivirus cross-reactivity, and long immunoglobulin M (IgM) persistence.

aimTo evaluate different methods for WNV detection [reverse transcription-polymerase chain reaction (RT-PCR), IgM/IgG antibodies, IgG avidity] in serum, cerebrospinal fluid (CSF), and urine samples of patients with confirmed WNV infection.

methodsThe study included patients with confirmed WNV neuroinvasive infection (

resultsThe WNV-RNA detection rates were significantly higher in the urine (54.5%)/serum (46.4%) than in CSF (32.2%). According to the sampling time, the WNV-RNA detection rates in urine collected within 7 days/8-14/≥ 15 days were 29.4/66.6/62.5% (

conclusionThe frequency of WNV RNA and antibody detection depends on the sampling time and type of clinical samples. IgG avidity could differentiate recent WNV infections from long-persisting IgM antibodies.

Indexed as

Cross-reactivityIgG avidityReverse transcription-polymerase chain reactionSerologyWest Nile virus

Identifiers

PMID39722752
PMCPMC11551685

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.