Observational studyEuropean journal of neurology2025
Effect of autoimmune comorbidities on multiple sclerosis course: An observational multicenter study.
Observational study in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cladribine use for multiple sclerosis with autoimmune comorbidities: retrospective analysis of the French MS registry, case series, and therapeutic considerations.Therapeutic advances in neurological disorders · 2026Article
- Effect of autoimmune comorbidities on multiple sclerosis course: An observational multicenter study.European journal of neurology · 2025Observational
- Comorbidities in newly diagnosed multiple sclerosis patients: A population-based register study in Finland.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study aims to examine the age and disability levels at diagnosis in people with multiple sclerosis (PwMS), with and without autoimmune comorbidities (AC), and the effect of AC on NEDA-3 status and to characterize AC associated with MS, comparing also therapeutic approaches between MS patients with and without other AC.
methodsThis population-based, multicentric study enrolled patients with relapsing-remitting MS (RRMS) with AC (AC group) or without AC (reference group) from 14 MS centers. Demographical, clinical features, treatment information, MRI activity, EDSS, and no evidence of disease activity (NEDA-3) status were assessed at T36 (enrollment time) and T0 (36 months prior).
resultsEight hundred seventy-three RRMS patients were included; 215 (24.7%) presented with at least one AC. The AC group was characterized by higher proportion of female patients than reference group (p = 0.008). Patients with AC, compared to reference group, exhibited older age at MS onset and MS diagnosis, and higher EDSS score at diagnosis, at T0 (all p < 0.001), and T36 (p = 0.03). The proportion of patients reaching EDSS 4 was higher in reference group than AC group (p = 0.03). People in AC group were more often treated with glatiramer acetate, natalizumab, and rituximab, whereas PwMS from reference group with interferon-beta and fingolimod at T0 and T36. The risk of losing NEDA-3 was lower in AC group (OR = 0.61, 95% CI 0.43-0.86, p = 0.005).
conclusionsAC are common in PwMS and can be related to a delay in onset, diagnosis and higher disability at MS presentation. However, the coexistence of AC is not associated with a worse prognosis.
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