Evidence map›Paper›PMID 39722487›Full record

ArticleCurrent protein & peptide science2025

Purification, Characterization, and Antimicrobial Activity Against

Amanda M A Moura, Jose Tadeu A Oliveira, Daniele O B Sousa, Lucas P Dias, Nadine M S Araujo, Raquel de O Rocha, Tawanny K B Aguiar, Joao M M Neto, Viviane O Silva, Ricardo M Feitosa and 3 more

Abstract read
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In one paragraph

Article in Current protein & peptide science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda M A MouraDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Jose Tadeu A OliveiraDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Daniele O B SousaDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Lucas P DiasDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Nadine M S AraujoDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Raquel de O RochaDepartment of Plant Pathology and Ecology, The Connecticut Agricultural Experiment Station, New Haven-CT 06511, USA.
Tawanny K B AguiarDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Joao M M NetoDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Viviane O SilvaDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Ricardo M FeitosaDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Queilane L S G ChavesDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Marcio V RamosDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.
Cleverson D T FreitasDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici, Fortaleza-Ceará, Brazil. CEP 60451-970.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClinic infections caused by various microorganisms are a public health concern. The rise of new strains resistant to traditional antibiotics has exacerbated the problem. Thus, the search for new antimicrobial molecules remains highly relevant.

methodsThe current study purified, characterized, and assessed the antimicrobial activity of a papain inhibitor from

resultsThe inhibitor was purified by heating the crude extract at 80°C for 30 min, followed by ion exchange chromatography on a DEAE cellulose column. The purification index was 9-fold, yielding 2.3%. SDS-PAGE and size exclusion chromatography revealed that the protease inhibitor (

Indexed as

Antifungal AgentsAnti-Infective AgentsCandida parapsilosisCystatinsPlant ProteinsSeedsStaphylococcus aureusTerminaliaHydrogen-Ion ConcentrationKineticsMicrobial Sensitivity TestsPapainAntifungal AgentsAnti-Infective AgentsCystatinsPapainPlant ProteinsCandidaprotease inhibitorproteinseed.Staphylococcus aureusTerminalia catappa

Identifiers

PMID39722487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.