Evidence map›Paper›PMID 39721985›Full record

ReviewClinical and experimental immunology2025

The role of neutrophils in allergic disease.

James Trayer, Johana Isaza-Correa, Lynne Kelly, Maeve Kelleher, Jonathan Hourihane, Aideen Byrne, Eleanor Molloy

Abstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James TrayerDiscipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.ORCID 0000-0002-9998-9976
Johana Isaza-CorreaDiscipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.
Lynne KellyDiscipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.ORCID 0000-0002-4782-1143
Maeve KelleherDepartment of Allergy, Children's Health Ireland at Crumlin, Dublin, Ireland.
Jonathan HourihaneDepartment of Allergy, Children's Health Ireland at Temple Street, Dublin, Ireland.
Aideen ByrneDiscipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.
Eleanor MolloyDiscipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.

Funding

Trinity College Dublin School of Medicine and Trinity Research
6 · The paper itself

Abstract

Neutrophils are short-lived cells of the innate immune system and represent 50-70% of the circulating leucocytes. Their primary role is antimicrobial defence which they accomplish through rapid migration to sites of inflammation followed by phagocytosis, degranulation, and the release of neutrophil extracellular traps (NETosis). While previously considered terminally differentiated cells, they have been shown to have great adaptability and to play a role in conditions ranging from cancer to autoimmunity. This review focuses on their role in allergic disease. In particular: their role as potential amplifiers of type 1 hypersensitivity reactions leading to anaphylaxis; their involvement in alternative pathways of food and drug allergy; their role in allergic rhinitis and asthma and neutrophil dysfunction in atopic dermatitis. The use of potential biomarkers and therapeutic targets is also discussed with a view to guiding future research.

Indexed as

HypersensitivityNeutrophilsAnaphylaxisAnimalsAsthmaBiomarkersDermatitis, AtopicExtracellular TrapsHumansImmunity, InnateBiomarkersanaphylaxisatopygranulocytePMNpolymorphonuclear cell

Identifiers

PMID39721985
PMCPMC11747999

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.