Evidence map›Paper›PMID 39721981›Full record

ArticleJournal of biophotonics2025

Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications.

April Mordi, Varsha Karunakaran, Umme Marium Mim, Eric Marple, Narasimhan Rajaram

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

April MordiDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.ORCID 0000-0002-4759-4657
Varsha KarunakaranDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
Umme Marium MimDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
Eric MarpleEmVision LLC, Loxahatchee, Florida, USA.
Narasimhan RajaramDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.ORCID 0000-0003-1224-8567

Funding

Unraveling Gene-Environment Interactions Shaping Metabolism: A Multi-Omics Analysis in DrosophilaP20GM139768 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Joanna Fiddler · 2021 to 2026
$17.0M
Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopyR01CA238025 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI RAJARAM, NARASIMHAN · 2019 to 2024
$2.0M
Development and testing of a clinically compatible multimodal spectroscopic probe for noninvasive sensing of tumor oxygenation and metabolism in oral cancerR15CA238861 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MULDOON, TIMOTHY J · 2020 to 2020
$419k
National Institute for General Medical Sciences (NIGMS) of the National Institutes of Health P20GM139768National Institute for General Medical Sciences (NIGMS) of the National Institutes of Health R01CA238025National Institute for General Medical Sciences (NIGMS) of the National Institutes of Health R15CA238861NCI NIH HHS R01 CA238025NCI NIH HHS R15 CA238861NIGMS NIH HHS P20 GM139768
6 · The paper itself

Abstract

We report on the development of a multimodal spectroscopy system, combining diffuse reflectance spectroscopy (DRS) and spatially offset Raman spectroscopy (SORS). A fiber optic probe was designed with spatially offset source-detector fibers to collect subsurface measurements for each modality, as well as ball lens-coupled fibers for superficial measurements. The system acquires DRS, zero-offset Raman spectroscopy (RS) and SORS with good signal-to-noise ratio. Measurements on chicken breast tissue demonstrate that both DRS and RS can acquire spectra from similar depths within tissue. Measurements acquired from the skin of a human volunteer demonstrate distinct Raman peaks at 937 and 1755 cm

Indexed as

Spectrum Analysis, RamanAnimalsChickensEquipment DesignHumansMelaninsSkinMelaninsdiffuse reflectance spectroscopymultimodal spectroscopyRaman spectroscopyspatially offset Raman spectroscopy

Identifiers

PMID39721981
PMCPMC11884968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.