Evidence map›Paper›PMID 39721712›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2024

A lymph node lesion of hyper IL-6 syndrome mimicking plasmacytoma, IgG4-related disease, and Castleman disease.

Kenta Matsui, Hiroshi Imai, Toshiaki Kobayashi, Minoru Mizutani, Midori Filiz Nishimura, Yasuharu Sato, Kennosuke Karube, Manato Okada, Miki Usui, Keiki Kawakami and 1 more

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In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kenta MatsuiDivision of Pathology and Laboratory Medicine, JA Suzuka General Hospital, Suzuka, Mie, Japan.
Hiroshi ImaiPathology Division, Mie University Hospital, Tsu, Mie, Japan.
Toshiaki KobayashiDepartment of Hematology and Oncology, JA Suzuka General Hospital, Suzuka, Mie, Japan.
Minoru MizutaniDepartment of Hematology and Oncology, JA Suzuka General Hospital, Suzuka, Mie, Japan.
Midori Filiz NishimuraDepartment of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Yasuharu SatoDepartment of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Kennosuke KarubeDepartment of Pathology and Laboratory Medicine, Nagoya University, Nagoya, Japan.
Manato OkadaDepartment of Hematology and Oncology, JA Suzuka General Hospital, Suzuka, Mie, Japan.
Miki UsuiDivision of Pathology and Laboratory Medicine, JA Suzuka General Hospital, Suzuka, Mie, Japan.
Keiki KawakamiDepartment of Hematology and Oncology, JA Suzuka General Hospital, Suzuka, Mie, Japan.
Tetsuya MurataDivision of Pathology and Laboratory Medicine, JA Suzuka General Hospital, Suzuka, Mie, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 72-year-old male patient presented fatigue, anemia, elevated total protein, IgG, IgG4, IL-6, and vascular endothelial growth factor (VEGF) levels. Initial diagnostics suspected multiple myeloma. A plane computed tomography (CT) scan showed pneumonia and the enlargement of generalized lymph nodes. A lymph node biopsy revealed a mix of immature and mature plasma cells, significant IgG4-positive cells, and IL-6-secreting plasma cells, mimicking plasmacytoma, IgG4-related disease, and Castleman disease, ultimately leading to a diagnosis of hyper IL-6 syndrome. Treatment with antibiotics improved the patient's condition without the need for additional therapies, including tocilizumab.

Indexed as

Castleman DiseaseImmunoglobulin G4-Related DiseaseInterleukin-6Lymph NodesPlasmacytomaAgedAntibodies, Monoclonal, HumanizedDiagnosis, DifferentialHumansImmunoglobulin GMaleSyndromeAntibodies, Monoclonal, HumanizedIL6 protein, humanImmunoglobulin GInterleukin-6tocilizumabCastleman diseasehyper interleukin-6 syndromeIgG4-related diseaseplasmacytoma

Identifiers

PMID39721712
PMCPMC11786147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.