Evidence map›Paper›PMID 39721702›Full record

ArticleJournal of atherosclerosis and thrombosis2025

Atherogenic Dyslipidemia Is Critically Related to Aortic Complicated Lesions in Cryptogenic Stroke.

Muneaki Kikuno, Yuji Ueno, Yohei Tateishi, Ayako Kuriki, Ryosuke Doijiri, Takahiro Shimizu, Hidehiro Takekawa, Kodai Kanemaru, Yoshiaki Shimada, Eriko Yamaguchi and 11 more

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In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Muneaki KikunoDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Yuji UenoDepartment of Neurology, Juntendo University Faculty of Medicine.
Yohei TateishiDepartment of Neurology and Strokology, Nagasaki University Hospital.
Ayako KurikiDepartment of Neurology, Showa University Koto Toyosu Hospital.
Ryosuke DoijiriDepartment of Neurology, Iwate Prefectural Central Hospital.
Takahiro ShimizuDepartment of Neurology, St. Marianna University School of Medicine.
Hidehiro TakekawaDepartment of Neurology, Dokkyo Medical University.
Kodai KanemaruDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Yoshiaki ShimadaDepartment of Neurology, Juntendo University Urayasu Hospital.
Eriko YamaguchiDepartment of Neurology, National Cerebral and Cardiovascular Center.
Masatoshi KogaDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Yuki KamiyaDepartment of Neurology, Showa University Koto Toyosu Hospital.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center.
Akira TsujinoDepartment of Neurology and Strokology, Nagasaki University Hospital.
Koichi HirataDepartment of Neurology, Dokkyo Medical University.
Yasuhiro HasegawaDepartment of Neurology, St. Marianna University School of Medicine.
Hitoshi AizawaDepartment of Neurology, Tokyo Medical University Hospital.
Hiroo TerashiDepartment of Neurology, Tokyo Medical University Hospital.
Nobutaka HattoriDepartment of Neurology, Juntendo University Faculty of Medicine.
Takao UrabeDepartment of Neurology, Juntendo University Urayasu Hospital.
CHALLENGE ESUS/CS collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAtherogenic dyslipidemia (AD) is regarded as a residual risk of cardiovascular diseases characterized by low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels and related to the intracranial stenosis of atheromatous thrombotic brain infarction (ATBI). Further, atherosclerosis is possibly related to another stroke subtype, including cryptogenic stroke (CS). In particular, an aortic complicated lesion (ACL) is a notable embolic source of CS, since recurrence of aortogenic brain embolism is not rare. This study aimed to clarify the underlying association between AD and CS.

methodsCHALLENGE ESUS/CS (Mechanisms of Embolic Stroke Clarified by Transesophageal Echocardiography for ESUS/CS) had extensive data from CS patients who underwent transesophageal echocardiography (TEE). AD was defined as HDL-C ≤ 40 mg/dl and TG ≥ 150 mg/dl. Based on these criteria, patients were divided into an AD group and a non-AD group to compare the clinical features.

resultsOf 664 CS patients (446 men, 68.7±12.8 years), 68 (10.2%) met the criteria of AD (AD group), and 596 (89.8%) were in the non-AD group. On multiple logistic regression analysis, body mass index (unit OR 1.11, 95%CI 1.04-1.19, p=0.002), diabetes mellitus (OR 2.23, 95%CI 1.28-3.87, p=0.004), ACL in the arch (OR 1.89, 95%CI 1.09-3.31, p=0.025), and deterioration during hospitalization (OR 3.96, 95%CI 1.32-10.68, p=0.009) were independently associated with AD.

conclusionAD was not rare in the present CS population. Moreover, AD was crucially related to ACL in CS. Therefore, intensive and pleiotropic lipid-modifying therapy would be efficacious for further treatment of aortogenic brain embolism.

Indexed as

Aortic DiseasesAtherosclerosisDyslipidemiasIschemic StrokeAgedEchocardiography, TransesophagealFemaleHumansMaleMiddle AgedPrognosisRisk FactorsTriglyceridesTriglyceridesAortic complicated lesionAtherogenic dyslipidemiaCryptogenic strokeEmbolic stroke of undetermined sourceTransesophageal echocardiography

Identifiers

PMID39721702
PMCPMC12237763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.