Evidence map›Paper›PMID 39721494›Full record

ArticleRedox biology2025

Generation of thiyl radicals in a spatiotemporal controlled manner by light: Applied for the cis to trans isomerization of unsaturated fatty acids/phospholipids.

Biswajit Roy, Ryota Kojima, Obaed Shah, Meg Shieh, Eshani Das, Shahrzad Ezzatpour, Emiko Sato, Yusuke Hirata, Stephen Lindahl, Atsushi Matsuzawa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Biswajit RoyDepartment of Chemistry, Brown University, Providence, RI, 02912, USA.
Ryota KojimaLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Obaed ShahDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA.
Meg ShiehDepartment of Chemistry, Brown University, Providence, RI, 02912, USA.
Eshani DasDepartment of Chemistry, Brown University, Providence, RI, 02912, USA.
Shahrzad EzzatpourDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA.
Emiko SatoDivision of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Yusuke HirataLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Stephen LindahlDepartment of Chemistry, Brown University, Providence, RI, 02912, USA.
Atsushi MatsuzawaLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Hector C AguilarDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA.
Ming XianDepartment of Chemistry, Brown University, Providence, RI, 02912, USA. Electronic address: ming_xian@brown.edu.

Funding

Mechanisms of Nipah virus fusion and entryR01AI109022 · NIAID · WASHINGTON STATE UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2014 to 2024
$4.3M
Explore the Chemistry and Chemical Biology of Reactive Sulfur SpeciesR35GM149170 · NIGMS · BROWN UNIVERSITY · PI Ming Xian · 2023 to 2026
$1.6M
Probing the cardioprotective effects of sulfane sulfurs with next generation fluorescent sensorsF31HL170516 · NHLBI · BROWN UNIVERSITY · PI SHIEH, MEG · 2023 to 2025
$146k
NHLBI NIH HHS F31 HL170516NIAID NIH HHS R01 AI109022NIGMS NIH HHS R35 GM149170
6 · The paper itself

Abstract

Thiyl radicals are important reactive sulfur species and can cause cis to trans isomerization on unsaturated fatty acids. However, biocompatible strategies for the controlled generation of thiyl radicals are still lacking. In this work, we report the study of a series of naphthacyl-derived thioethers as photo-triggered thiyl radical precursors. Tertiary naphthacyl thioether was identified to be a suitable template that could be used to produce both aryl and alkyl thiyl radicals under ultraviolet (UV) light or sunlight. The effective cis-to trans-isomerization of unsaturated fatty acid models (methyl oleate, methyl linoleate) and a natural phospholipid (cardiolipin) using these photo-triggered substrates was demonstrated. This reaction was also proved to proceed effectively in cells to produce thiyl radicals and subsequent fatty acid isomerization. Additionally, the most promising thiyl radical precursor showed antiviral activity in a pseudotyped virus model, likely due to disrupting viral lipid membranes upon UV activation. These findings highlight the potential of thiyl radicals for both biochemical and antiviral applications.

Indexed as

Fatty Acids, UnsaturatedPhospholipidsSulfidesAnimalsFree RadicalsHumansIsomerismLightLinoleic AcidsUltraviolet RaysFatty Acids, UnsaturatedFree RadicalsLinoleic Acidsmethyl linoleatePhospholipidsSulfidesCis to trans isomerizationPhotoreactionThioetherThiyl radicalsUnsaturated fatty acid

Identifiers

PMID39721494
PMCPMC11732231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.