Evidence map›Paper›PMID 39721219›Full record

ReviewCurrent opinion in chemical biology2025

Microbial metabolism of host-derived antioxidants.

Zhe Zhou, Stavroula K Hatzios

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhe ZhouDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA; Microbial Sciences Institute, Yale University, West Haven, CT, 06516, USA.
Stavroula K HatziosDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA; Microbial Sciences Institute, Yale University, West Haven, CT, 06516, USA; Department of Chemistry, Yale University, New Haven, CT, 06520, USA. Electronic address: stavroula.hatzios@yale.edu.

Funding

Understanding redox-regulated mechanisms of environmental adaptation in gastrointestinal symbiontsR35GM137952 · NIGMS · YALE UNIVERSITY · PI Stavroula Hatzios · 2020 to 2026
$3.1M
Chemoproteomic discovery and functional characterization of infection-induced oxidation sitesR01AI182086 · NIAID · YALE UNIVERSITY · PI Stavroula Hatzios · 2024 to 2026
$2.1M
NIAID NIH HHS R01 AI182086NIGMS NIH HHS R35 GM137952
6 · The paper itself

Abstract

Humans are exposed to a wide variety of small molecules with antioxidant properties that are poorly metabolized by mammalian cells. However, gastrointestinal microbes encode enzymes that convert these redox-active molecules into nutrient sources and electron acceptors to support bacterial growth in the gut. Here, we describe recent studies highlighting how microbial metabolism of host-derived antioxidants modulates interspecies interactions and provide an overview of the interdisciplinary approaches being used to map these metabolic pathways in vivo. Uncovering microbe-driven biotransformations of redox-active small molecules could create new opportunities to improve human health by modulating redox reactions at the host-microbe interface.

Indexed as

AntioxidantsBacteriaGastrointestinal MicrobiomeHost Microbial InteractionsAnimalsHumansOxidation-ReductionAntioxidantsAntioxidantsBacterial metabolismGut microbiomeHost–microbe interactionsMetabolomics

Identifiers

PMID39721219
PMCPMC11863140

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.