Evidence map›Paper›PMID 39721002›Full record

ArticleJournal of cellular and molecular medicine2024

CCL2/CCR2 Signalling in Mesenchymal Stem/Progenitor Cell Recruitment and Fracture Healing in Mice.

Rahasudha Kannan, Amy J Koh, Robert N Kent, Kaira Bhutada, Fatima Wasi, Leon Wagner, Kenneth Kozloff, Brendon M Baker, Hernan Roca, Laurie K McCauley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rahasudha KannanDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Amy J KohDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Robert N KentDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Kaira BhutadaDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Fatima WasiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Leon WagnerDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Kenneth KozloffDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Hernan RocaDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID 0000-0003-2896-1455
Laurie K McCauleyDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID 0000-0001-9173-9123

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Tumor microvesicle-mediated modulation of the bone microenvironmentP01CA093900 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KELLER, EVAN T · 2004 to 2024
$29.6M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
PTH and Calcium Synergy for Craniofacial RegenerationR01DE022327 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2012 to 2022
$3.8M
Biomimetic Apoptotic Particles for Macrophage-driven Oral Bone RegenerationF31DE030697 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KANNAN, RAHASUDHA · 2021 to 2025
$152k
NCI NIH HHS P01 CA093900NIAMS NIH HHS P30 AR069620NIDCR NIH HHS F31 DE030697NIDCR NIH HHS R01 DE022327NIGMS NIH HHS T32 GM007863NIH HHS AR069620NIH HHS CA093900NIH HHS DE022327NIH HHS DE030697
6 · The paper itself

Abstract

Macrophage efferocytosis (clearance of apoptotic cells) is crucial for tissue homeostasis and wound repair, where macrophages secrete factors that promote resolution of inflammation and regenerative signalling. This study examined the role of efferocytic macrophage-associated CCL2 secretion, its influence on mesenchymal stem/progenitor cell (MSPC) chemotaxis, and in vivo cell recruitment using Ccr2

Indexed as

Chemokine CCL2Fracture HealingMesenchymal Stem CellsMice, KnockoutReceptors, CCR2Signal TransductionAnimalsApoptosisMacrophagesMaleMiceMice, Inbred C57BLCcl2 protein, mouseCcr2 protein, mouseChemokine CCL2Receptors, CCR2C‐C motif chemokine ligand 2efferocytosisfracture healingosteoimmunologyosteoprogenitor

Identifiers

PMID39721002
PMCPMC11669326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.