Evidence map›Paper›PMID 39720956›Full record

ReviewClinical and experimental medicine2024

Cancer vaccines: an update on recent achievements and prospects for cancer therapy.

Arezki Chekaoui, Mariangela Garofalo, Beata Gad, Monika Staniszewska, Jacopo Chiaro, Katarzyna Pancer, Aleksander Gryciuk, Vincenzo Cerullo, Stefano Salmaso, Paolo Caliceti and 4 more

Abstract readReview
In one paragraph

Review in Clinical and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Cancer Vaccines: Mobilizing Immunity for Targeted Cancer Therapy.Asian Pacific journal of cancer prevention : APJCP · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arezki ChekaouiDepartment of Virology, National Institute of Public Health NIH-National Research Institute, Warsaw, Poland.
Mariangela GarofaloDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy. mariangela.garofalo@unipd.it.
Beata GadDepartment of Virology, National Institute of Public Health NIH-National Research Institute, Warsaw, Poland.
Monika StaniszewskaCentre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland.
Jacopo ChiaroDrug Research Program (DRP), ImmunoViroTherapy Lab (IVT), Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Katarzyna PancerDepartment of Virology, National Institute of Public Health NIH-National Research Institute, Warsaw, Poland.
Aleksander GryciukCentre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland.
Vincenzo CerulloDrug Research Program (DRP), ImmunoViroTherapy Lab (IVT), Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Stefano SalmasoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Paolo CalicetiDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Aleksander MasnyDepartment of Virology, National Institute of Public Health NIH-National Research Institute, Warsaw, Poland.
Magdalena WieczorekDepartment of Virology, National Institute of Public Health NIH-National Research Institute, Warsaw, Poland.
Sari PesonenValo Therapeutics Oy, Helsinki, Finland.
Lukasz KurykDepartment of Virology, National Institute of Public Health NIH-National Research Institute, Warsaw, Poland. lkuryk@pzh.gov.pl.

Funding

European Commission CN00000041Narodowe Centrum Badań i Rozwoju 0258/L-14/2023Narodowe Centrum Nauki 2022/47/D/NZ7/03212National Institute of Public Health NIH - National Research Institute BW-3/2024Università degli Studi di Padova GAR- O_STARS_MUR22_01
6 · The paper itself

Abstract

Decades of basic and translational research have led to a momentum shift in dissecting the relationship between immune cells and cancer. This culminated in the emergence of breakthrough immunotherapies that paved the way for oncologists to manage certain hard-to-treat cancers. The application of high-throughput techniques of genomics, transcriptomics, and proteomics was conclusive in making and expediting the manufacturing process of cancer vaccines. Using the latest research technologies has also enabled scientists to interpret complex and multiomics data of the tumour mutanome, thus identifying new tumour-specific antigens to design new generations of cancer vaccines with high specificity and long-term efficacy. Furthermore, combinatorial regimens of cancer vaccines with immune checkpoint inhibitors have offered new therapeutic approaches and demonstrated impressive efficacy in cancer patients over the last few years. In the present review, we summarize the current state of cancer vaccines, including their potential therapeutic effects and the limitations that hinder their effectiveness. We highlight the current efforts to mitigate these limitations and highlight ongoing clinical trials. Finally, a special focus will be given to the latest milestones expected to transform the landscape of cancer therapy and nurture hope among cancer patients.

Indexed as

Cancer VaccinesImmunotherapyNeoplasmsAntigens, NeoplasmClinical Trials as TopicHumansImmune Checkpoint InhibitorsAntigens, NeoplasmCancer VaccinesImmune Checkpoint Inhibitorscancer immunitycancer vaccinecancer vaccine platformsimmunotherapytumour resistance

Identifiers

PMID39720956
PMCPMC11669620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.