Evidence map›Paper›PMID 39720891›Full record

ArticleJournal of cellular and molecular medicine2024

Myeloperoxidase and Thyrotropin-Releasing Hormone Within Leukaemia Stem Cells Increased Chemosensitivity in Acute Myeloid Leukaemia.

Chung-Hsing Chen, Tsung-Chih Chen, Ting-Shuan Wu, Tzu-Hung Hsiao, Jo-Mei Maureen Chen, Chi-Ying F Huang, Po-Liang Cheng, Jia-Rung Tsai, Chieh-Lin Jerry Teng

Abstract read
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In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chung-Hsing ChenDepartment of Mathematics, University of Taipei, Taipei, Taiwan.ORCID 0000-0002-1205-7368
Tsung-Chih ChenDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Ting-Shuan WuDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan.
Tzu-Hung HsiaoDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Jo-Mei Maureen ChenDepartment of Applied Chemistry, National Chi Nan University, Puli, Nantou, Taiwan.
Chi-Ying F HuangInstitute of Biopharmaceutical Sciences, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Po-Liang ChengDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Jia-Rung TsaiDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Chieh-Lin Jerry TengDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0001-9744-0368

Funding

Health Promotion Administration, Ministry of Health and Welfare MOHW112-TDU-B-222-124014National Science and Technology Council NSTC 112-2314-B-005 -011Taichung Veterans General Hospital TCVGH-NHRI111009Taichung Veterans General Hospital TCVGH-YM1120101
6 · The paper itself

Abstract

Leukaemia stem cells (LSCs) are major contributors to chemoresistance in acute myeloid leukaemia (AML). Identifying potential biomarkers within LSCs that can predict chemosensitivity in AML is key. This prospective study involved 20 consecutive de novo AML patients who underwent '7 + 3' induction therapy. The patients were divided into CR (n = 15) and non-CR (n = 5) groups. Using single-cell RNA sequencing, we examined the cellular states of bone marrow mononuclear cells from AML patients at diagnosis and identified LSC among these cells. Our results showed that in non-CR AML patients, a significant increase in the proportion of immature cells during haematopoiesis within the AML cell populations was observed. Moreover, the expression of myeloperoxidase (MPO) (log

Indexed as

Leukemia, Myeloid, AcuteNeoplastic Stem CellsPeroxidaseAdultAgedBiomarkers, TumorDrug Resistance, NeoplasmFemaleHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkers, TumorMPO protein, humanPeroxidaseAMLchemosensitivityleukaemic stem cellsMPOTRH

Identifiers

PMID39720891
PMCPMC11669111

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.