Evidence map›Paper›PMID 39720700›Full record

ArticleMolecular therapy. Nucleic acids2024

DNA aptamers that modulate biological activity of model neurons.

Jenelle Rolli, Keenan Pearson, Brandon Wilbanks, Sybil C L Hrstka, Andrew P Minotti, Lorenz Studer, Arthur E Warrington, Nathan P Staff, L James Maher

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Methods for cell- and tissue-specific DNA aptamer selection.Molecular therapy. Methods & clinical development · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenelle RolliDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Keenan PearsonDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Brandon WilbanksDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Sybil C L HrstkaDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Andrew P MinottiThe Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA.
Lorenz StuderThe Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA.
Arthur E WarringtonDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Nathan P StaffDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
L James MaherDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Cell Intrinsic and Extrinsic Factors Driving Maturation in Human PSC-derived NeuronsR01NS128087 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LORENZ P. STUDER · 2023 to 2026
$2.6M
Fundamental and applied studies of nucleic acidsR35GM143949 · NIGMS · MAYO CLINIC ROCHESTER · PI LOUIS JAMES MAHER · 2022 to 2026
$1.9M
Loss of nuclear integrity is sufficient to induce age-associated changes and Alzheimer's pathology in hPSC-derived cortical neurons.F31AG067709 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI MINOTTI, ANDREW · 2020 to 2022
$138k
NCI NIH HHS P30 CA008748NIA NIH HHS F31 AG067709NIGMS NIH HHS R35 GM143949NINDS NIH HHS R01 NS128087
6 · The paper itself

Abstract

There is an urgent need for agents that promote health and regeneration of cells and tissues, specifically to treat diseases of the aging nervous system. Age-associated nervous system degeneration and various diseases are driven by many different biochemical stresses, often making it difficult to target any one disease cause. Our laboratory has previously identified DNA aptamers with apparent regenerative properties in murine models of multiple sclerosis by selecting aptamers that bind oligodendrocyte membrane preparations. Here, we selected from vast libraries of molecules (∼10

Indexed as

aptamerdifferentiationin vitro selectionMT: Oligonucleotides: Therapies and ApplicationsneuriteRNA-seqSH-SY5Y

Identifiers

PMID39720700
PMCPMC11667033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.