Evidence map›Paper›PMID 39720669›Full record

ArticleExperimental and therapeutic medicine2025

Prostate artery embolization as an effective treatment for clinically significant prostate cancer‑related hemorrhage: A case report.

Diomidis Kozyrakis, Vasilios Konstantinopoulos, Panagiotis Papaspyridakos, Anastasios Zarkadas, Dimitrios Bozios, Athanasios Karmogiannis, Georgios Haronis, Anna-Maria Konomi, Georgios Kallinikas, Konstantinos Safioleas and 4 more

Abstract readCase Reports
In one paragraph

Article in Experimental and therapeutic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Diomidis KozyrakisDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Vasilios KonstantinopoulosDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Panagiotis PapaspyridakosDepartment of Interventional Radiology, KAT Hospital, 14561 Kifisia, Greece.
Anastasios ZarkadasDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Dimitrios BoziosDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Athanasios KarmogiannisDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Georgios HaronisDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Anna-Maria KonomiDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Georgios KallinikasDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Konstantinos SafioleasDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Despoina MytiliniouDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Athanasios FiliosDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Evaggelos RodinosDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.
Panagiotis FiliosDepartment of Urology, Konstantopouleio-Patision General Hospital of Nea Ionia, 14233 Nea Ionia, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 79-year old Caucasian male with metastatic hormone refractory prostate cancer and bilateral nephrostomy was admitted to the emergency department due to 4-day bloody urethral discharge, weakness and dizziness. The patient was treated with the luteinizing hormone-releasing hormone-antagonist and abiraterone acetate plus prednisone, dabigatran 150 mg bid (for atrial fibrillation and coronary heart disease) and 5-aminosalicylic acid for the management of mild ulcerative colitis. Imaging revealed bladder overdistention and blood analysis low levels of hematocrit (HCT) and hemoglobin (HGB) (HCT, 22%; HGB, 7.1 gr/dl). A 22F, 3-way urethral catheter was placed, and blood clots were removed with a syringe. Continuous normal saline irrigation was initiated, and the dabigatran was withdrawn; however, no evidence of control of blood loss was shown. Computed tomography and urography revealed a large prostate lesion invading the bladder neck, a pelvic lymph-node block and lack of blood extravasation. Diagnostic urethrocystoscopy revealed diffuse hematuria from the prostate lesion and bladder neck. Bipolar coagulation was performed in the absence of any significant improvement. Upon withdrawal of intravesical irrigation, the oral consumption of a large water volume (a useful measure to control hematuria and avoid clot formation) could not be applied to the patient due to urine storage and normal voiding being not feasible. Subsequently, the patient was informed on the option of superselective arterial embolization (SAE). Following signing of the relevant consent form, the patient underwent bilateral SAE of prostatic and inferior cystic arteries, while he was in heparin delivery. Dabigatran was re-administered on the 5th postprocedural day and the catheter was removed following 5 days. Following a 4-month follow-up, the patient's condition was stable with no traceable hematuria. In conclusion, the minimal invasiveness of SAE is an attractive option, notably in patients with cardiovascular comorbidities. It appears to be a safe alternative with an acceptable rate of minor complications. The encouraging results and the survival outcomes warrant further evaluation with comparative prospective multicenter studies.

Indexed as

arterycancerembolizationhemorrhageprostate

Identifiers

PMID39720669
PMCPMC11667420

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.