Evidence map›Paper›PMID 39720657›Full record

ArticleFrontiers in medicine2024

Case report: Primary infection of conjunctival histoplasmosis mimicking a large conjunctival neoplasm in an immunosuppressed patient.

Jonathan Lam, Rumana Hussain, Sarah E Coupland, Heinrich Heimann

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan LamSt Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
Rumana HussainSt Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
Sarah E CouplandSt Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
Heinrich HeimannSt Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of a rapidly growing and large conjunctival histoplasmosis lesion in an immunosuppressed West African woman in her 80s, affecting her only eye. The patient had undergone a renal transplant and was on immunosuppressive medications. Additionally, she had previously been treated for presumed systemic histoplasmosis with itraconazole more than 5 years ago. Despite receiving previous treatment, she presented with a large conjunctival lesion, which was confirmed to be histoplasmosis after an excisional biopsy. The lesion was observed to grow over a 2-week period, causing significant visual impairment. Following a comprehensive systems review and investigation, the conjunctiva was identified as the sole site of infection. This case underscores the rarity of sight-threatening Histoplasma infections in the conjunctiva of an immunosuppressed individual. Conjunctival histoplasmosis lesions are rarely reported, with even fewer cases documented as primarily originating from this location.

Indexed as

amphotericin Bconjunctival tumorhistoplasmosisimmunosuppressionmasquerade

Identifiers

PMID39720657
PMCPMC11667548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.