Evidence map›Paper›PMID 39720621›Full record

ArticleBlood and genomics discovery2025

Alterations of T Cell Subsets Associated with Sickle Cell Trait.

Alexander P Reiner, Laura M Raffield, Lynette Ekunwe, Nels C Olson, Paul L Auer, Margaret F Doyle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood and genomics discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA 98105, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Lynette EkunweJackson Heart Study, Jackson, MS 39216, USA.
Nels C OlsonDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA.
Paul L AuerDivision of Biostatistics, Institute for Health and Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Margaret F DoyleDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA.

Funding

Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Next generation functional genomics of hematology traitsR01HL146500 · NHLBI · UNIVERSITY OF WASHINGTON · PI ALEXANDER P REINER · 2020 to 2026
$5.7M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Immune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart StudyR01AG075884 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Laura M Raffield · 2022 to 2026
$3.7M
Thrombosis genetics in African AmericansR01HL132947 · NHLBI · UNIVERSITY OF WASHINGTON · PI LANGE, LESLIE A, REINER, ALEXANDER P · 2017 to 2020
$3.1M
NHLBI NIH HHS HHSN268201800015INHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL132947NHLBI NIH HHS R01 HL146500NHLBI NIH HHS U01 HL120393NIA NIH HHS R01 AG075884
6 · The paper itself

Abstract

Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system, we performed flow cytometry of monocyte and lymphocyte immune cell subsets from peripheral blood mononuclear cells collected in a large, community-based cohort of SCT-positive (n = 68) and SCT-negative (n = 959) Black adults. SCT was significantly associated with lower proportions of CD8

Indexed as

CD4CD8Flow CytometrySickle CellT Lymphocyte

Identifiers

PMID39720621
PMCPMC11665108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.