Evidence map›Paper›PMID 39720530›Full record

ArticleiScience2024

The molecular basis of pH sensing by the human fungal pathogen

Rían W Manville, Claire L Illeck, Anthony Lewis, Zoe A McCrossan, Steven A N Goldstein, Geoffrey W Abbott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rían W ManvilleBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Claire L IlleckBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Anthony LewisSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT Hants, UK.
Zoe A McCrossanNIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC), University of Southampton, Southampton, SO16 7NS Hampshire, UK.
Steven A N GoldsteinDepartments of Physiology & Biophysics, Pediatrics, and Pharmaceutical Sciences, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Geoffrey W AbbottBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

Funding

Ion Channel Transporter InteractionsR35GM130377 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Geoffrey W Abbott · 2019 to 2026
$4.0M
hHv1 channels in neutrophils and the innate immune inflammatory responseR01HL159711 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDSTEIN, STEVE A N, ZHAO, RUIMING · 2022 to 2025
$2.4M
NHLBI NIH HHS R01 HL159711NIGMS NIH HHS R35 GM130377
6 · The paper itself

Abstract

Two-pore domain, outwardly rectifying potassium (TOK) channels are exclusively expressed in fungi. Human fungal pathogen TOK channels are potential antifungal targets, but TOK channel modulation in general is poorly understood. Here, we discovered that

Indexed as

Biological sciencesMicrobial physiologyMicrobiologyNatural sciences

Identifiers

PMID39720530
PMCPMC11667011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.