Evidence map›Paper›PMID 39720407›Full record

ArticleFrontiers in veterinary science2024

Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues.

Mojtaba Daneshi, Pawel P Borowicz, Mara R Hirchert, Yssi L Entzie, Jessica G Syring, Layla E King, Kazi Sarjana Safain, Muhammad Anas, Lawrence P Reynolds, Alison K Ward and 3 more

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In one paragraph

Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mojtaba DaneshiDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Pawel P BorowiczDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Mara R HirchertDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Yssi L EntzieDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Jessica G SyringDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Layla E KingDepartment of Agriculture and Natural Resources, University of Minnesota Crookston, Crookston, MN, United States.
Kazi Sarjana SafainDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Muhammad AnasDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Lawrence P ReynoldsDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Alison K WardDepartment of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, Canada.
Carl R DahlenDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.
Matthew S CrouseUnited States Department of Agriculture, Agriculture Research Service, U.S. Meat Animal Research Center, Clay Center, NE, United States.
Joel S CatonDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Maternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate immunity. This study investigated the effects of maternal nutrient restriction and OCM supplementation on mRNA expression of AMP in fetal and maternal lung, mammary gland, and small intestine of beef cattle. Methods: Twenty-nine crossbred Angus beef heifers were synchronized for estrus and artificially inseminated. They were assigned to one of four treatments in a 2 × 2 factorial design: nutritional plane [control (CON) vs. restricted (RES)] and OCM supplementation [without OCM (-OCM) or with OCM (+OCM)]. Heifers on the CON diet were fed to gain 0.45 kg/day, while RES heifers were fed to lose 0.23 kg/day. Treatments were applied from day 0 to 63 of gestation, after which all heifers were fed a common diet to gain 0.45 kg/day until day 161 of gestation, when samples were collected. Quantitative RT-qPCR was used to assess mRNA expression of AMP. Results: Nutritional plane had no effect ( Discussion: Our findings suggest that while restricted maternal nutrition did not affect mRNA expression of AMP, OCM supplementation modulated AMP expression in both fetal and maternal tissues. Further research is needed to elucidate the mechanisms underlying OCM's impact on AMP expression.

Indexed as

cathelicidinsdevelopmental programmingearly pregnancyepigenetic modificationsinnate immunitynutrition restrictionone-carbon metabolismβ-defensins

Identifiers

PMID39720407
PMCPMC11666495

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.