Evidence map›Paper›PMID 39720354›Full record

ArticleCase reports in women's health2024

Prenatal diagnosis of clinodactyly and its association with genetic syndromes: A case report.

Themistoklis Loukopoulos, Athanasios Zikopoulos, Nikolaos Vlassis, Emmanouil Manolakos, Sotirios Sotiriou, Anastasia Vatopoulou, Fani Gkrozou, Anastasios Potiris, Sofoklis Stavros, Charikleia Skentou

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Article in Case reports in women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Themistoklis LoukopoulosDepartment of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece.
Athanasios ZikopoulosDepartment of Obstetrics and Gynecology, Royal Devon and Exeter Hospital, Barrack Rd, Exeter EX2 5DW, UK.
Nikolaos VlassisObstetrician & Gynecologist, Private Practice, Lamia, Greece.
Emmanouil ManolakosAccess To Genome-ATG, Clinical Laboratory Genetics, Athens, Greece.
Sotirios SotiriouDepartment of Embryology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Anastasia VatopoulouDepartment of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece.
Fani GkrozouDepartment of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece.
Anastasios PotirisDepartment of Obstetrics and Gynecology, University Hospital of Attikon Athens, Greece.
Sofoklis StavrosDepartment of Obstetrics and Gynecology, University Hospital of Attikon Athens, Greece.
Charikleia SkentouDepartment of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A curvature of a finger that bends inwards relative to the other fingers is a common observation during prenatal screening. When the angulation exceeds 10 degrees, it is known as "clinodactyly" and could suggest a variety of underlying issues. Even though it usually remains unnoticed during pregnancy, it may be a sign of serious fetal disease. We report the case of a fetus diagnosed with clinodactyly of the thumb accompanied by tachycardia, abnormal levels of maternal hormones in the first trimester and increased impedance to flow in the uterine arteries. Although non-invasive prenatal testing was normal, amniocentesis was carried out and two deviations at chromosome 20 were identified through molecular karyotyping. Our report aims to raise clinical suspicion regarding the potential association between genetic abnormalities and clinodactyly. A careful clinical and genetic consultation is required in order to achieve the most favorable outcome for both mother and child.

Indexed as

ClinodactylyGenetic counselingMolecular karyotypingPrenatal ultrasound

Identifiers

PMID39720354
PMCPMC11667062

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