Trial reportDrug design, development and therapy2024
Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid-Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial.
Trial report in Drug design, development and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The 15° left tilt position during caesarean delivery has been recommended by guidelines for many years, but recent studies have questioned the clinical benefit of left tilt position. We hypothesize that using a higher starting dose of metaraminol in the supine position will result in a non-inferior umbilical arterial pH, compared to the 15° left tilt position. Methods: Healthy women undergoing elective caesarean delivery were randomized to the supine position (n = 62) or 15° left tilt position (n = 62) after spinal anaesthesia (0.5% bupivacaine 9 mg). Different starting doses of metaraminol infusion were initiated at 2.7 μg kg Results: Compared with tilt group, pH (supine group: 7.325 (7.29, 7.35) vs tilt group: 7.33 (7.3, 7.35), P = 0.76) and base excess (tilt group: -0.98 (2.59) mM vs supine group: -0.92 (2.77) mM, P = 0.9) of the umbilical artery are non-inferior. There was no difference in SBP (P = 0.16) or incidence of hypotension (P = 0.75) between the two groups. The incidence of reactive hypertension was greater in the supine position group (P < 0.001). Conclusion: If maternal blood pressure is maintained using the higher starting dose of metaraminol, the left tilted position may not be necessary among healthy patients (BMI less than 35 kg/m
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