Evidence map›Paper›PMID 39720233›Full record

ArticleSmall structures2024

Enoki-Inspired Microfibers and Extracellular Matrix Enhance Biaxially Interlocking Interfaces.

Huy Tran, Navatha Shreem Polavaram, Zishuo Yan, Donghee Lee, Yizhu Xiao, S M Shatil Shahriar, Zheng Yan, Jingwei Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small structures, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huy TranDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Navatha Shreem PolavaramDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Zishuo YanDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Donghee LeeDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yizhu XiaoDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
S M Shatil ShahriarDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Zheng YanDepartment of Chemical and Biomedical Engineering, University of Missouri, Columbia, MO, 65211, USA.
Jingwei XieDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Funding

Biomimetic and Injectable Highly Porous Nanofiber Microsphere-based Platform for Alveolar Bone RegenerationR01DE031272 · NIDCR · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jingwei Xie · 2022 to 2026
$2.0M
Multifunctional Intelligent Hierarchical Fibrous Biomaterials Integrated with Multimodal Biosensing and Feedback-Based Interventions for Healing Infected Chronic WoundsR56EB034685 · NIBIB · UNIVERSITY OF MISSOURI-COLUMBIA · PI XIE, JINGWEI, YAN, ZHENG · 2023 to 2023
$777k
NIBIB NIH HHS R56 EB034685NIDCR NIH HHS R01 DE031272
6 · The paper itself

Abstract

Taking inspiration from diverse interlocking and adhesion structures found in nature, a biaxially interlocking interface is developed in this work. This interface is formed by interconnecting two electrostatically flocked substrates and its mechanical strength is enhanced through the incorporation of enoki mushroom-shaped microfibers and deposited extracellular matrix (ECM). Tips of flocked straight fibers can be transformed into mushroom shapes through thermal treatment. The tensile strength of interlocked scaffolds with mushroom-shaped tips drastically increased when compared to scaffolds made of straight fibers, which was not reported previously. More cells proliferate within interlocked scaffolds with mushroom-shaped tips than scaffolds with straight fibers. Additionally, the mechanical strength (e.g., compressive, tensile, and shear) of cell-seeded interlocked scaffolds increased proportionally to the amount of ECM deposited by dermal fibroblasts. The biaxially interlocking interface developed in this study holds promise for applications in engineering interfacial tissues, modelling tissue interfaces, investigating tissue-tissue interactions, and facilitating tissue bridging or binding.

Indexed as

electrostatic flockingEnoki-inspired microfibersextracellular matrix depositioninterlocking interfacemechanical properties

Identifiers

PMID39720233
PMCPMC11666250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.