Evidence map›Paper›PMID 39720182›Full record

ArticleFrontiers in genetics2024

Integration of single-cell and bulk analysis reveals TBXAS1 as a key platelet-related gene causing poor prognosis in osteosarcoma.

Han Liu, Wacili Da, Jianhua Mu, Xuanhong He, Zhuangzhuang Li, Taojun Gong, Jingjing Wang, Li Min, Minxun Lu, Chongqi Tu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Han Liu *Department of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Wacili Da *Department of Orthopedics Surgery, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
Jianhua MuDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Xuanhong HeDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Zhuangzhuang LiDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Taojun GongDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Jingjing WangDepartment of Endocrine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Li MinDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Minxun LuDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Chongqi TuDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Platelets are associated with poor prognosis in most tumors, but their specific pathogenic mechanism in osteosarcoma is not yet clear. The objective of this study is to conduct an in-depth analysis of how genes closely related to platelet function impact the prognosis of osteosarcoma patients. We hope that through this research, we can uncover the potential mechanisms of these genes in the development and progression of osteosarcoma, thereby providing new therapeutic strategies and theoretical foundations for improving the prognosis of osteosarcoma patients. Method: We collected the blood routine test data of patients who were initially diagnosed with osteosarcoma at the Department of Bone Tumors, West China Hospital, from January 2012 to January 2022. By applying the LASSO-COX regression analysis, a statistical method, we found that the platelet count is associated with the prognosis of osteosarcoma patients. To further explore this relationship, we obtained single-cell data and bulk RNA data of osteosarcoma patients from the TARGET database and GEO database, respectively. By analyzing these data, we revealed at the transcriptomic level how platelets contribute to the poor prognosis in osteosarcoma patients. Result: Platelets are associated with the prognosis of osteosarcoma patients (HR = 3.9, 95% CI = 1.9-8.1, Conclusion: TBXAS1 is a key platelet-related gene that leads to poor prognosis in osteosarcoma, and this gene may affect the prognosis of osteosarcoma patients by interacting with macrophages.

Indexed as

blood plateletsmacrophagesosteosarcomaprognosissingle cell

Identifiers

PMID39720182
PMCPMC11667113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.