Evidence map›Paper›PMID 39720155›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Targeting Na

Erick J Rodríguez-Palma, Santiago Loya-Lopez, Sophia M Min, Aida Calderon-Rivera, Kimberly Gomez, Rajesh Khanna, Alison D Axtman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Development of a Second-Generation,Journal of medicinal chemistry · 2025
    Article
  4. R and S enantiomers of CBD3063, a CaNeurobiology of pain (Cambridge, Mass.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erick J Rodríguez-PalmaDepartment of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Santiago Loya-LopezDepartment of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Sophia M MinStructural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Aida Calderon-RiveraDepartment of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kimberly GomezDepartment of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Rajesh KhannaDepartment of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Alison D AxtmanStructural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

CRMP2, mitochondria, and Huntington’s diseaseR01NS098772 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUSTOVETSKY, NICKOLAY, KHANNA, RAJESH · 2017 to 2021
$2.8M
Sentrin proteases, CRMP2 deSUMOylation, and Chronic PainR01NS120663 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2020 to 2021
$2.6M
CRMP2, Nav1.7 sodium channel, and chronic painR01DA042852 · NIDA · UNIVERSITY OF ARIZONA · PI KHANNA, RAJESH · 2017 to 2021
$1.9M
NIDA NIH HHS R01 DA042852NINDS NIH HHS R01 NS098772NINDS NIH HHS R01 NS120663
6 · The paper itself

Abstract

PIKfyve (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays an important role in generating phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P

Indexed as

Neuropathic painPharmacokineticsPIKfyve inhibitorSensory neuronsSodium channels

Identifiers

PMID39720155
PMCPMC11665415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.