Evidence map›Paper›PMID 39719974›Full record

ArticleFrontiers in neurology2024

Characteristics of peripheral immune response induced by large-vessel occlusion in patients with acute ischemic stroke.

Ling Ma, Bin Sun, Chenliu Fan, Juan Xiao, Maomao Geng, Jie Liu, Runze Jiang, Yang Jiang, Dianwei Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling MaDepartment of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong, China.
Bin SunDepartment of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Chenliu FanHematology Department, The Second Hospital of Shandong University, Jinan, Shandong, China.
Juan XiaoHematology Department, The Second Hospital of Shandong University, Jinan, Shandong, China.
Maomao GengDepartment of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Jie LiuDepartment of Clinical Laboratory, Weihai Haida Hospital, Weihai, Shandong, China.
Runze JiangJinan Biomedical Industry Academy of Shandong First Medical University, Jinan, Shandong, China.
Yang JiangHematology Department, The Second Hospital of Shandong University, Jinan, Shandong, China.
Dianwei LiuDepartment of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Despite improvements in the treatment of acute ischemic stroke (AIS), some patients still suffer from functional impairments, indicating the poor understanding of pathophysiologic process of AIS. Inflammation plays an important role in the pathophysiology of AIS. The purpose of the study was to investigate the peripheral inflammation in different subtypes of AIS. Methods: Here, retrospective data from AIS with large vessel occlusion (LVO) and small vessel occlusion (SVO), and healthy controls, were initially analyzed. Then, flow cytometry was performed to evaluate the levels of peripheral naïve and memory T-cells. Finally, we characterized the T cell receptors (TCR) repertoire using high-throughput sequencing. Results: Elevated levels of leukocytes, neutrophils, and neutrophil-to-lymphocyte ratio (NLR), and decreased levels of lymphocytes were found in LVO group than that in SVO group, which were correlated with the severity of LVO. In addition, higher percentages of both effector memory (Tem) and central memory (Tcm) T cells, and lower percentage of naïve T cells in CD4 Discussion: In conclusion, AIS with LVO can rapidly induce peripheral immune response, which provides new insight into the understanding of pathophysiology of AIS.

Indexed as

acute ischemic strokeCD45large vessel occlusionT cellT cell receptors repertoire

Identifiers

PMID39719974
PMCPMC11666556

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