Evidence map›Paper›PMID 39719969›Full record

ArticleCurrent opinion in behavioral sciences2025

How Dopamine Enables Learning from Aversion.

Gabriela C Lopez, Talia N Lerner

Abstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Sense of agency and decision making.Frontiers in psychology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gabriela C LopezFeinberg School of Medicine, Department of Neuroscience, Northwestern University, Chicago, IL, USA.
Talia N LernerFeinberg School of Medicine, Department of Neuroscience, Northwestern University, Chicago, IL, USA.

Funding

Rodent Behavior CoreP50DA044121 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RADULOVIC, JELENA · 2018 to 2022
$9.0M
How Early-Life Experiences Create Individual Variation in Dopamine Circuit Architecture: Understanding Risk for Psychiatric DiseaseDP2MH122401 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LERNER, TALIA NEWCOMBE · 2019 to 2022
$2.5M
Plasticity and Function of Dopamine Circuits Regulating the Transition to HabitR01MH125885 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jones G Parker · 2023 to 2026
$2.0M
Chronic Pain Modulation of Mesolimbic Dopamine Signaling for Natural and Opiate RewardsF31DA056200 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LOPEZ, GABRIELA CAROLINA · 2022 to 2024
$129k
NIDA NIH HHS F31 DA056200NIDA NIH HHS P50 DA044121NIMH NIH HHS DP2 MH122401NIMH NIH HHS R01 MH125885
6 · The paper itself

Abstract

Dopamine is heavily studied for its role in reward learning, but it is becoming increasingly appreciated that dopamine can also enable learning from aversion. Dopamine neurons modulate their firing and neurotransmitter release patterns in response to aversive outcomes. However, there is considerable heterogeneity in the timing and directionality of the modulation. Open questions remain as to the factors that determine this heterogeneity and how varying patterns of responses to aversion in different dopamine-receptive brain regions contribute to value learning, decision-making, and avoidance. Here, we review recent progress in this area and highlight important future directions.

Indexed as

aversionavoidancedecision-makingDopaminelearningpunishmentreinforcement

Identifiers

PMID39719969
PMCPMC11666190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.