Evidence map›Paper›PMID 39719929›Full record

ArticleHuman brain mapping2024

Therapeutic DBS for OCD Suppresses the Default Mode Network.

Natalya Slepneva, Genevieve Basich-Pease, Lee Reid, Adam C Frank, Tenzin Norbu, Andrew D Krystal, Leo P Sugrue, Julian C Motzkin, Paul S Larson, Philip A Starr and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Natalya SlepnevaWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Genevieve Basich-PeaseWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Lee ReidDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.
Adam C FrankDepartment of Psychiatry and Behavioral Sciences, Keck School of Medicine of USC, Los Angeles, California, USA.
Tenzin NorbuWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Andrew D KrystalWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Leo P SugrueWeill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0000-0001-7315-4519
Julian C MotzkinWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Paul S LarsonDepartment of Neurosurgery, University of Arizona, Tucson, Arizona, USA.
Philip A StarrWeill Institute for Neurosciences, University of California, San Francisco, California, USA.
Melanie A MorrisonWeill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0000-0002-5993-0515
A Moses LeeWeill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0000-0003-0531-102X

Funding

TRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERSR25MH060482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H MATHALON, Susan M. Voglmaier · 2000 to 2026
$5.2M
Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human BrainK23MH125018 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES · 2021 to 2025
$1.0M
Targeting DBS Therapy to the OCD Network Using fMRI and Intracranial RecordingsR21MH130914 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES, MORRISON, MELANIE A · 2022 to 2023
$444k
Deeda Blair Research InitiativeNew Venture FundNIMH NIH HHS K23MH125018NIMH NIH HHS R21 MH130914NIMH NIH HHS R21MH130914NIMH NIH HHS R25 MH060482
6 · The paper itself

Abstract

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is a circuit-based treatment for severe, refractory obsessive-compulsive disorder (OCD). The therapeutic effects of DBS are hypothesized to be mediated by direct modulation of a distributed cortico-striato-thalmo-cortical network underlying OCD symptoms. However, the exact underlying mechanism by which DBS exerts its therapeutic effects still remains unclear. In five participants receiving DBS for severe, refractory OCD (3 responders, 2 non-responders), we conducted a DBS On/Off cycling paradigm during the acquisition of functional MRI (23 fMRI runs) to determine the network effects of stimulation across a variety of bipolar configurations. We also performed tractography using diffusion-weighted imaging (DWI) to relate the functional impact of DBS to the underlying structural connectivity between active stimulation contacts and functional brain networks. We found that therapeutic DBS had a distributed effect, suppressing BOLD activity within regions such as the orbitofrontal cortex, dorsomedial prefrontal cortex, and subthalamic nuclei compared to non-therapeutic configurations. Many of the regions suppressed by therapeutic DBS were components of the default mode network (DMN). Moreover, the estimated stimulation field from the therapeutic configurations exhibited significant structural connectivity to core nodes of the DMN. Based upon these findings, we hypothesize that the suppression of the DMN by ALIC DBS is mediated by interruption of communication through structural white matter connections surrounding the DBS active contacts.

Indexed as

Deep Brain StimulationDefault Mode NetworkMagnetic Resonance ImagingObsessive-Compulsive DisorderAdultDiffusion Tensor ImagingFemaleHumansInternal CapsuleMaleMiddle AgedNerve Netanterior limb of the internal capsuledeep brain stimulationdefault mode networkDTIfMRIOCDtractography

Identifiers

PMID39719929
PMCPMC11668941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.