Evidence map›Paper›PMID 39719891›Full record

ArticleMolecular microbiology2025

Environmental Control of Queuosine Levels in Streptococcus mutans tRNAs.

Marshall Jaroch, Kathryn Savage, Paul Kuipers, Jo Marie Bacusmo, Jennifer Hu, Jingjing Sun, Peter C Dedon, Kelly C Rice, Valérie de Crécy-Lagard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marshall JarochDepartment of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.
Kathryn SavageDepartment of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.
Paul KuipersDepartment of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.
Jo Marie BacusmoDepartment of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.
Jennifer HuDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jingjing SunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Peter C DedonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Kelly C RiceDepartment of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-1335-4409
Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-9955-3785

Funding

Synthesis and function of Queuosine in BacteriaR01GM070641 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2006 to 2023
$5.3M
Translational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9M
Translational regulation during cigarette smoking-induced reprogramming of the tRNA epitranscriptome, in vitro and in a mouse smoking modelR01ES031529 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI BEGLEY, THOMAS J · 2020 to 2024
$1.9M
National Research Foundation SingaporeNIEHS NIH HHS ES026856NIEHS NIH HHS ES031529NIEHS NIH HHS R01 ES026856NIEHS NIH HHS R01 ES031529NIGMS NIH HHS GM70641NIGMS NIH HHS R01 GM070641
6 · The paper itself

Abstract

Queuosine (Q) is a modification of the wobble base in tRNAs that decode NA(C/U) codons. It is ubiquitous in bacteria, including many pathogens. Streptococcus mutans is an early colonizer of dental plaque biofilm and a key player in dental caries. Using a combination of genetic and physiological approaches, the predicted Q synthesis and salvage pathways were validated in this organism. These experiments confirmed that S. mutans can synthesize Q de novo through similar pathways found in Bacillus subtilis and Escherichia coli. However, S. mutans has a distinct salvage pathway compared to these model organisms, as it uses a transporter belonging to the energy coupling factor (ECF) family controlled by a preQ

Indexed as

Bacillus subtilisNucleoside QRNA, TransferStreptococcus mutansBiofilmsEscherichia coliGene Expression Regulation, BacterialRiboswitchNucleoside QRiboswitchRNA, Transferbiofilmoral pathogenpreQ0preQ1riboswitchtRNA modification

Identifiers

PMID39719891
PMCPMC11724357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.