Evidence map›Paper›PMID 39719467›Full record

ArticleDigestive diseases and sciences2025

Association Between Serum Uric Acid and Non-alcoholic Fatty Liver Disease in Non-obese Young Population: A Prospective Cohort Study.

Yunpeng Li, Xiangming Ma, Shuqing Cui, Guochao Jiang, Jianguo Jia, Xinyu Ge, Liying Cao

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yunpeng Li *Graduate School of North, China University of Science and Technology, Tangshan, China.
Xiangming Ma *Graduate School of North, China University of Science and Technology, Tangshan, China.
Shuqing Cui *Graduate School of North, China University of Science and Technology, Tangshan, China.
Guochao JiangGraduate School of North, China University of Science and Technology, Tangshan, China.
Jianguo JiaDepartment of Hepatobiliary Surgery, Kailuan General Hospital, Tangshan, 063000, China.
Xinyu GeGraduate School of North, China University of Science and Technology, Tangshan, China.
Liying CaoGraduate School of North, China University of Science and Technology, Tangshan, China. maxiangming@tmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe prevalence of non-alcoholic fatty liver disease (NAFLD) is gradually increasing among non-obese people and shows a trend of younger age. The objective of this study was to investigate the potential association between serum uric acid (SUA) and NAFLD in a non-obese young population. PATIENTS AND

methodsThe study recruited 10,938 participants without NAFLD (18 ≤ age < 45,18.5 ≤ BMI < 25) in 2006. After a median follow-up of 9.95 years, 4835 (44.20%) participants were diagnosed with NAFLD. According to the baseline SUA level, the research subjects were divided into 4 groups by the quartile method. The association between SUA and NAFLD was predicted using the Kaplan -Meier survival curve and Cox hazard regression model.

resultsAfter adjusting for all the confounders, the HRs and 95%CI for NAFLD in the quartile 2, quartile 3 and quartile 4 were 1.095(1.004 ~ 1.193), 1.195(1.095 ~ 1.304) and 1.409(1.289 ~ 1.541). The restrictive cubic spline (RCS) functions confirmed the existence of a non-linear association between the initial SUA and NAFLD (non-linearity association P < 0.05). Kaplan-Meier Survival Curve shows that the risk of NAFLD increased with increasing levels of SUA. The cumulative incidences of the four groups were 46.19, 51.99, 56.52 and 65.87%, respectively (log-rank test P < 0.001).

conclusionIt has been confirmed through a prospective cohort study that in non-obese young population, SUA can serve as an independent predictor of NAFLD. An increase in SUA within the physiological range, even if it doesn't reach the level of hyperuricemia, can impose a significant burden on the occurrence of NAFLD.

trial registrationTrial registration number: ChiCTR-TNC-11001489, registration site: http://www.chictr.org.cn/index.aspx .

Indexed as

Non-alcoholic Fatty Liver DiseaseUric AcidAdolescentAdultBiomarkersFemaleHumansMaleProspective StudiesRisk FactorsYoung AdultBiomarkersUric AcidNon-alcoholic fatty liver diseaseNon-obese young peopleProspective cohort studySerum uric acid

Identifiers

PMID39719467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.