Evidence map›Paper›PMID 39719249›Full record

ArticleContemporary clinical trials2025

A one-day acceptance and commitment therapy workshop for the prevention of chronic post-surgical pain and long-term opioid use following spine surgery: Protocol for a pilot feasibility randomized controlled trial.

Jolin B Yamin, Bethany D Pester, Ramya Kommu, Caroline Allen, Diya Dharmendran, Kylie Steinhilber, Madelyn Crago, Savannah Kazemipour, Angelina Franqueiro, Delia Fentazi and 4 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jolin B YaminDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: jyamin@bwh.harvard.edu.
Bethany D PesterDepartment of Anesthesiology and Pain Medicine, University of Washington Medicine, Seattle, WA, USA.
Ramya KommuDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; University of Indianapolis, Indianapolis, IN, USA.
Caroline AllenDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Diya DharmendranDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Texas A&M University, College Station, TX, USA.
Kylie SteinhilberDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Madelyn CragoUniversity of Massachusetts Medical School, Worcester, MA, USA.
Savannah KazemipourLake Erie College of Osteopathic Medicine, Erie, PA, USA.
Angelina FranqueiroDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Delia FentaziDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kristin L SchreiberDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Robert R EdwardsDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Robert N JamisonDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Samantha M MeintsDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Funding

PREventing Pain after Surgery: A feasibility and acceptability study of Acceptance and Commitment Therapy for the prevention of chronic post surgical pain (PREPS)K23AR077088 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI MEINTS, SAMANTHA M · 2021 to 2025
$1.0M
Mentorship in Precision Pain Medicine via EPPIC-NETK24NS126570 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2021 to 2021
$319k
NIAMS NIH HHS K23 AR077088NINDS NIH HHS K24 NS126570
6 · The paper itself

Abstract

backgroundBack pain is increasingly common, leading to more spine surgeries. While most people experience pain relief and improved function after surgery, many continue to suffer from chronic post-surgical pain (CPSP) with limited functional improvement. CPSP is often treated with opioids, raising concerns about misuse, poor functional outcomes, and broader public health impacts. Therefore, perioperative interventions are needed to enhance outcomes and reduce the risk of opioid misuse after surgery.

objectiveThis article outlines a study protocol evaluating the feasibility, acceptability, and preliminary efficacy of a brief, perioperative Acceptance and Commitment Therapy (ACT) intervention aimed at improving pain and reducing opioid use after spine surgery.

designIn this pilot randomized controlled trial, participants scheduled for spine surgery (anticipated N = 100) are assigned to the ACT intervention or a treatment-as-usual group.

interventionThe ACT intervention is a 5-h, single-session, virtual workshop with a booster call two weeks post-workshop or post-surgery, whichever is later. OUTCOME MEASURES: The primary outcome is patient-reported treatment helpfulness immediately after the intervention. Secondary outcomes include patient-reported treatment credibility and expectancy post-intervention, treatment helpfulness at 1 month post-surgery, and pain interference, pain intensity and opioid use at 1, 3, and 6 months post-surgery.

conclusionThis pilot trial examines a novel, brief ACT intervention aimed at preventing CPSP and reducing opioid dependence. If successful, feasibility and preliminary efficacy results will be utilized to inform a future, full-scale randomized trial of this intervention.

Indexed as

Acceptance and Commitment TherapyAnalgesics, OpioidChronic PainOpioid-Related DisordersPostoperative PainSpineAdultFeasibility StudiesFemaleHumansMalePilot ProjectsRandomized Controlled Trials as TopicAnalgesics, OpioidAcceptance and commitment therapyACTChronic painOpioidSpine surgery

Identifiers

PMID39719249
PMCPMC11788048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.