ArticleThe Journal of international medical research2024
Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults.
Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Association between a history of hypothyroidism and incident chronic kidney disease and potential mediators: A cohort study with Mendelian randomization analysis.The Journal of international medical research · 2025Article
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6 authors.
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Abstract
objectiveTo explore the relationship between leukocyte count and renal function in patients with lupus nephritis (LN).
methodsWe performed a retrospective cross-sectional study of 100 patients with LN admitted to the Department of Nephrology between 1 January 2015 and 30 December 2023. Based on tertile of leukocyte count, they were allocated to Low, Medium, or High groups. The demographic, clinical, and pathologic characteristics of the groups were compared and the relationship between leukocyte count and renal function was analyzed using multiple linear regression analysis.
resultsAfter adjustment for age, albumin, 24-hour proteinuria, serum complement factor 3, hemoglobin, blood pressure, systemic lupus erythematosus disease activity index score, and histologic parameters, a linear relationship was identified between leukocyte count and renal function (regression coefficient -2.852; 95% confidence interval: -5.161, -0.543). Therefore, for every 1 × 10
conclusionThere is an independent linear relationship between leukocyte count and renal function. Leukocyte recruitment into the kidney is a critical step in the progression of LN, and as the leukocyte count increases, renal function gradually declines. Leukocyte count may represent a sensitive biomarker of the progression and prognosis of LN.
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