Evidence map›Paper›PMID 39718906›Full record

ArticleOrganic letters2025

Mild and Chemoselective Triethylsilane-Mediated Debenzylation for Phosphate Synthesis.

Luke E Hodson, Paul Joseph Tholath, Leon Jacobs, Nicole Pribut, Gouthami Pashikanti, Aletta E van der Westhuyzen, David Laws, Dennis C Liotta

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luke E HodsonDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0001-9779-1133
Paul Joseph TholathDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0009-0005-0495-4594
Leon JacobsDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-8717-3654
Nicole PributDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0003-0439-9162
Gouthami PashikantiDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0009-0002-9015-2413
Aletta E van der WesthuyzenDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
David LawsDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0001-5828-717X
Dennis C LiottaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7736-7113

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthetic utility of tetrabenzyl pyrophosphate for achieving chemoselective phosphorylation of phenols, as well as primary, secondary, and tertiary alcohols, is reported here. Additionally, we introduce a rapid, mild, and chemoselective debenzylation procedure, enabling access to phosphates in the presence of redox sensitive groups. Finally, stoichiometrically controlled monodebenzylation provides a versatile platform for late-stage divergent synthesis of phosphodiester and phosphoramidate chemical libraries.

Identifiers

PMID39718906
PMCPMC11731398

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.