Evidence map›Paper›PMID 39718712›Full record

ReviewProbiotics and antimicrobial proteins2025

Antioxidant and Antimicrobial Properties of Probiotics: Insights from In Vitro Assays.

Fernanda Farias Costa, Tatielle Gomes Dias, Priscila Mendonça Mendes, Jesse Pereira Machado Viana, Eveline Brandão Madeira, Ana Lúcia Fernandes Pereira, Adriana Gomes Nogueira Ferreira, Marcelino Santos Neto, Richard Pereira Dutra, Aramys Silva Reis and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Antimicrobial efficacy ofMicrobiology spectrum · 2026
    Article
  3. Article
  4. Probiotic Spores ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernanda Farias CostaCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil.ORCID 0009-0003-5561-2610
Tatielle Gomes DiasGraduate Program in Health Sciences, Federal University of Maranhão, São Luís, Maranhão, Brazil.ORCID 0000-0001-8446-2592
Priscila Mendonça MendesGraduate Program in Health Sciences, Federal University of Maranhão, São Luís, Maranhão, Brazil.ORCID 0000-0003-3621-5364
Jesse Pereira Machado VianaGraduate Program in Molecular Biology, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Distrito Federal, Brazil.ORCID 0000-0002-0117-8439
Eveline Brandão Madeira, Imperatriz, Maranhão, Brazil.ORCID 0000-0003-0057-8016
Ana Lúcia Fernandes PereiraCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil.ORCID 0000-0001-6562-252X
Adriana Gomes Nogueira FerreiraCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil.ORCID 0000-0002-7107-1151
Marcelino Santos NetoCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil.ORCID 0000-0002-6105-1886
Richard Pereira DutraCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil.ORCID 0000-0001-6880-9736
Aramys Silva ReisCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil.ORCID 0000-0003-4999-6382
Márcia Cristina Gonçalves MacielCenter for Sciences of Imperatriz, Graduate Program in Health and Technology, Federal University of Maranhão, Imperatriz, Maranhão, Brazil. marcia.maciel@unb.br.ORCID 0000-0001-8782-4923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics are microorganisms that provide health benefits at adequate doses and exhibit notable antioxidant and antimicrobial activities. These properties play crucial roles in combating chronic diseases linked to oxidative stress and antimicrobial resistance. This review aimed to summarize the antioxidant and antimicrobial properties of probiotics determined in in vitro studies and discuss mechanistic actions and analysis methods. The MEDLINE (PubMed), Web of Science, Scopus, Science Direct, and Embase databases were utilized. The included articles demonstrated the antioxidant and antimicrobial activities of both isolated and food matrix-associated probiotics, with the most common genera being Lactobacillus, Bifidobacterium, Saccharomyces, and Streptococcus. Antioxidant activity was the most studied property, yielding varied results attributed to evaluation tests and probiotic strain. Antibacterial activity was consistently reported in all studies. Additionally, fermentation with probiotic microorganisms improved the content and bioaccessibility of bioactive compounds. In conclusion, analysis results highlight the antioxidant and antimicrobial activity of probiotics reported in in vitro studies. They enhance bioactive content and bioaccessibility and produce novel beneficial metabolites during fermentation. These results reinforce the therapeutic promise of probiotics associated with plant matrices and indicate the need for clinical studies to confirm their efficacy in improving human health.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntioxidantsProbioticsBifidobacteriumFermentationHumansLactobacillusAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsBacteriocinsBioactivesBiotransformationFermented foodsNutraceuticals

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.