Trial reportSurgery today2025
Ninjin'yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study.
Trial report in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study evaluated the efficacy of ninjin'yoeito for alleviating postoperative symptoms after lung cancer surgery.
methodsOverall, 140 patients who underwent lobectomy were randomized into a conventional treatment group and a ninjin'yoeito group. The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function.
resultsThe mean change in the CFS score 8 weeks postoperatively was - 5.56 in the ninjin'yoeito group and - 5.53 in the conventional treatment group (P = 0.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8 weeks postoperatively were - 5.60 and - 3.38 in the ninjin'yoeito and conventional groups, respectively, with a difference of - 1.95 (P = 0.049). The changes in the mean vital capacity 8 weeks postoperatively were - 340.5 mL in the ninjin'yoeito group and - 473.5 mL in the conventional treatment group, with a difference of + 135.1 mL (P = 0.041). The ninjin'yoeito group had a significantly lower proportion of patients with malnutrition 16 weeks postoperatively than the conventional treatment group (P = 0.040).
conclusionThe results of this study show that ninjin'yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.
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