Evidence map›Paper›PMID 39718563›Full record

ArticleThe Journal of cell biology2025

Directed stochasticity: Building biomolecular condensates in the right place.

Mark S Geisler, James P Kemp, Robert J Duronio

Abstract read
In one paragraph

Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark S Geisler *Curriculum in Genetics and Molecular Biology, University of North Carolina , Chapel Hill, NC, USA.ORCID 0000-0002-2900-4609
James P Kemp *Integrative Program for Biological and Genome Sciences, University of North Carolina , Chapel Hill, NC, USA.ORCID 0000-0003-1975-1149
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina , Chapel Hill, NC, USA.ORCID 0000-0001-6469-6965

Funding

HISTONE MRNA REGULATION IN DEVELOPMENTR01GM058921 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MARZLUFF, WILLIAM F. · 1999 to 2025
$11.6M
Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
The Mute button: Turning down the volume of histone expressionF31HD113267 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GEISLER, MARK STEPHEN · 2023 to 2025
$146k
NICHD NIH HHS F31 HD113267NIGMS NIH HHS R01 GM058921NIGMS NIH HHS R35 GM145258
6 · The paper itself

Abstract

Controlling biomolecular condensate formation within the nucleus is critical for genome function. In this issue, Xu et al. (https://doi.org/10.1083/jcb.202401036) report that KPNA3 promotes histone locus body formation and expression of replication-dependent histone genes by both importing NPAT into the nucleus and preventing NPAT condensation from improperly occurring in the cytoplasm.

Indexed as

Biomolecular CondensatesCell Nucleusalpha KaryopherinsAnimalsCytoplasmHistonesHumansalpha KaryopherinsHistones

Identifiers

PMID39718563
PMCPMC11668170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.