Evidence map›Paper›PMID 39718377›Full record

ArticleAnnals of human genetics2025

Identifying a Genetic Link Between Lung Function and Psoriasis.

Kazuya Tanimura, Melinda C Aldrich, James Jaworski, Jinchuan Xing, Satoshi Okawa, Divay Chandra, Seyed M Nouraie, Toru Nyunoya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kazuya TanimuraDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Melinda C AldrichDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
James JaworskiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jinchuan XingDepartment of Genetics, Human Genetic Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA.
Satoshi OkawaDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Divay ChandraDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Seyed M NouraieDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Toru NyunoyaDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-0688-4607

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Role of FBXO24 mediated ubiquitination of FoxP1 protein in the pathogenesis and treatment of COPDR01HL153400 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHANDRA, DIVAY · 2020 to 2024
$2.3M
Role of TACC2 in smoking-induced COPDR01HL149719 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NYUNOYA, TORU · 2020 to 2023
$1.6M
Automated Storage and Retrieval of Biological SystemsS10RR025141 · NCRR · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2008 to 2008
$988k
American Heart AssociationBLRD VA I01 BX006096CSRD VA I01 CX000105NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHLBI NIH HHS R01 HL149719NHLBI NIH HHS R01 HL153400NIH HHSU.S. Department of Veterans Affairs
6 · The paper itself

Abstract

introductionThe common genetic underpinnings of psoriasis and pulmonary comorbidities have yet to be explored. MATERIAL AND

methodsIn this cross-sectional study, we investigated the single-nucleotide polymorphisms (SNPs) associated with psoriasis and their relationship with pulmonary function using data from the UK Biobank (UKBB) and the Vanderbilt University Medical Center Biobank (BioVU).

resultsOut of the 63 psoriasis-associated SNPs identified in previous genome-wide association studies within the European population, we successfully identified 53 SNPs, including proxy SNPs in UKBB database. Following adjustments using age and sex, 31 SNPs displayed statistically significant associations with psoriasis. Among these, 16 SNPs exhibited significant associations with forced expiratory volume in 1 s (FEV

conclusionThis study has unveiled genetic variants that bridge the realms of psoriasis and lung function. The genes associated with these variants, including IFIH1, Grancalcin gene (GCA), and NFKB inhibitor alpha gene (NFKBIA), regulate innate immune responses, which suggests that immunodysregulation, a central element in psoriasis pathogenesis, may also impact lung function, alluding to a "skin-lung axis."

Indexed as

LungPolymorphism, Single NucleotidePsoriasisAdultAgedAllelesCross-Sectional StudiesFemaleForced Expiratory VolumeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedRespiratory Function TestsUnited Kingdomcomorbiditypolymorphismpsoriasissingle nucleotidespirometry

Identifiers

PMID39718377
PMCPMC11982659

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.