Evidence map›Paper›PMID 39717996›Full record

ArticleJournal of intellectual disability research : JIDR2025

Factors Associated With Depression in Caregivers of Adults With Down Syndrome.

Amy E Bodde, Brian C Helsel, Jessica Danon, Joseph Sherman, Anna Rice, Kristine Williams, Bethany Forseth, Joseph E Donnelly, Lauren T Ptomey

Abstract read
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Caregiving for Adults With Down Syndrome: Caregiver Experiences and Support Needs.Journal of applied research in intellectual disabilities : JARID · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amy E BoddeDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-8143-8105
Brian C HelselDepartment of Neurology, The University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0003-3362-3581
Jessica DanonDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Joseph ShermanDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Anna RiceDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Kristine WilliamsSchool of Nursing, The University of Kansas Medical Center, Kanas City, Kansas, USA.
Bethany ForsethDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, The University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-4321-6034
Joseph E DonnellyDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Lauren T PtomeyDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-1705-1643

Funding

longitudinal assessment of stress and stress-related concepts across a behavioral weight loss interventionP20GM144269 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Felicia Steger, John P Thyfault · 2022 to 2026
$14.9M
Institutional Career Development CoreKL2TR002367 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MATTHEW W MOSCONI, NICOLE L NOLLEN · 2017 to 2026
$7.3M
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down SyndromeR01AG063909 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DONNELLY, JOSEPH E., PTOMEY, LAUREN TAYLOR · 2019 to 2023
$3.9M
Assessment of Physical Activity for Alzheimer's Disease Research in Down SyndromeK01AG083130 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Brian Helsel · 2023 to 2026
$501k
Human Energy Balance Core at the Kansas Center for Metabolism and Obesity Research, National Institute of General Medical Sciences P20GM144269National Institute of Aging AG063909National Institute of Aging AG083130NCATS NIH HHS KL2 TR002367NCATS NIH HHS KL2TR002367NIA NIH HHS K01 AG083130NIA NIH HHS R01 AG063909NIGMS NIH HHS P20 GM144269
6 · The paper itself

Abstract

backgroundFamily caregivers of those with developmental disabilities have higher rates of depression and anxiety compared with caregivers of those without development disability. Few studies have examined factors that contribute to caregiver depression, including the appraisal of caregiving responsibilities and the physical fitness and daily function of the care recipient. The purpose of this study was to identify intrapersonal (caregiver) and interpersonal (care recipient) factors associated with depressive symptoms in caregivers of adults with Down syndrome (DS).

methodsTwenty-four adults with DS participating in a 12-month physical activity trial completed physical fitness and function tests (VO

resultsAdults with DS were 23 ± 7.5 years, 58% female; caregivers were 54 ± 10 years, 100% female, 96% family members. Caregiver depressive symptoms were significantly associated with caregiving distress (p = 0.024) and caregiving QoL (r = -0.58, p = 0.003). Hand grip strength of care recipients was inversely correlated with caregiver depressive symptoms (r = -0.45, p = 0.03), but other assessments of physical function and ADL were not associated with caregiver depressive symptoms.

conclusionsCaregiver depressive symptoms were related to modifiable factors related to the caregiver and care recipient. Intervening to improve caregiving appraisal and functional strength of the care recipient may positively impact caregiver mental health.

Indexed as

CaregiversDepressionDown SyndromePhysical FitnessQuality of LifeActivities of Daily LivingAdultFemaleHumansMaleMiddle AgedYoung AdultcaregiversdepressionDown syndromefitnessparentsphysical function

Identifiers

PMID39717996
PMCPMC11794010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.