Evidence map›Paper›PMID 39717896›Full record

ArticleeLife2024

Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis.

Jian Liu, YuYing Jiang, ZiYue Diao, DanDan Chen, RuiYuan Xia, BingWei Wang, Shuo Yang, ZhiQiang Yin

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Single-Cell Genetic Mapping of Gasdermin Expression Across Immune-Mediated Inflammatory Diseases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jian Liu *Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
YuYing Jiang *Department of Immunology, State Key Laboratory of Reproductive Medicine and Offspring Health, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Gusu School, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-3263-7730
ZiYue Diao *Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
DanDan ChenDepartment of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
RuiYuan XiaDepartment of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
BingWei WangDepartment of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, China.
Shuo YangDepartment of Immunology, State Key Laboratory of Reproductive Medicine and Offspring Health, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Gusu School, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing, China.
ZhiQiang YinDepartment of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-6510-1051

Funding

National Natural Science Foundation of China 82073439National Natural Science Foundation of China 82373475
6 · The paper itself

Abstract

Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell-related abnormalities. Pyroptosis is a type of regulated cell death associated with innate immunity, but its role in psoriasis is unclear. In this study, we found that

Indexed as

InflammationIntracellular Signaling Peptides and ProteinsNeutrophilsPhosphate-Binding ProteinsPsoriasisPyroptosisAnimalsFemaleGasderminsHumansMaleMiceMice, Inbred C57BLSkinGasderminsGSDMD protein, humanGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding Proteinsgasdermin Dhumanimmunologyinflammationmouseneutrophilpsoriasispyroptosistreatment

Identifiers

PMID39717896
PMCPMC11668524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.