ArticleIJID regions2025
Emerging lineages A2.2.1 and A2.2.2 of human metapneumovirus (hMPV) in pediatric respiratory infections: Insights from India.
Article in IJID regions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Trends of severe human metapneumovirus infections in India.BMC infectious diseases · 2026Article
- Burden of Human Metapneumovirus in India: Epidemiological Trends and Clinical Impact.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Review
- A Review of Respiratory Infection Caused by the Human Metapneumovirus: Occurrence, Epidemiology, Pathogenesis, Public Health Outcomes, and Intervention Strategies.Health science reports · 2026Article
- Avian Metapneumovirus: Virology, Epidemiology, and Insights from a Comparative Analysis with Human Metapneumovirus-A Review.Biomolecules · 2026Review
- Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches.Scientific reports · 2025Article
- Severe Manifestations of Human Metapneumovirus With Co-infections: A Case Series and Literature Review.Cureus · 2025Article
- Structural insights into natural compound inhibitors of the human metapneumovirus nucleocapsid protein via molecular dynamics and free energy landscape analyses.Scientific reports · 2025Article
- Molecular Epidemiology of Human Metapneumovirus Infections in Children from San Luis Potosí-Mexico.Viruses · 2025Article
- The re-emergence of HMPV: a wake-up call for public health systems.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Epidemiology of Human Metapneumovirus (HMPV) in India: a cross-sectional study.The Lancet regional health. Southeast Asia · 2025Article
- Immunological insights into the re-emergence of human metapneumovirus.Current opinion in immunology · 2025Review
- A multi-centre study on epidemiology and clinical characteristics of human metapneumovirus infection in Sri Lanka from 2021 to 2024.Access microbiology · 2025Article
- A Narrative Review of Current Updates, Advancements, and Evolving Landscape in Public Health Research of Human Metapneumovirus.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineReview
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Human metapneumovirus (hMPV) is recognized as a significant cause of acute respiratory infections among infants under 5 years of age. Methods: Nasal swabs collected from January 2021 to June 2024 were screened to detect hMPV using reverse transcription-quantitative polymerase chain reaction. Furthermore, representative positive samples were sequenced and subjected to phylogenetic analysis. Results: Of 4519 samples tested, 113 were positive for hMPV. Notably, an outbreak occurred between November 2022 and March 2023, where 56 of 583 (9.6%) patients tested positive. Analysis of the outbreak samples revealed that majority (6.3%) of cases occurred in December and January. hMPV infection was more prevalent in less than 1 year, with 29 (67%) patients with a history of wheezing and 3 (6.9%) with seizures. On the genetic analysis of F protein, 37 samples identified two genotypes as A and B, with subclusters of 29 (85.29%) samples to A2.1, 1 (2.94%) to A2.2.1, and 4 (11.76%) to A2.2.2 within genotype A and one sample clustered with B1 and 2 samples to B2 within genotype B. Conclusions: The study underscores the significant prevalence and genetic diversity of hMPV in children in Puducherry, India. Notably, the identification of novel A2.2.1 and A2.2.2 lineages highlights the evolving nature of hMPV.
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