Evidence map›Paper›PMID 39717852›Full record

ReviewToxicology reports2024

A systematic review of pesticide exposure, associated risks, and long-term human health impacts.

Chander Shekhar, Reetu Khosya, Kushal Thakur, Danish Mahajan, Rakesh Kumar, Sunil Kumar, Amit Kumar Sharma

Abstract readReview
In one paragraph

Review in Toxicology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Review
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  5. Molecules (Basel, Switzerland) · 2026
    Review
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  16. Recent Advances in TiOInternational journal of molecular sciences · 2026
    Review
  17. Article
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  20. New insights on the role of some biometals in mancozeb induced hematological and hepatorenal toxicity in rats and the protective effect of naringin.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chander ShekharDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.
Reetu KhosyaDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.
Kushal ThakurDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.
Danish MahajanDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.
Rakesh KumarDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.
Sunil KumarDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.
Amit Kumar SharmaDepartment of Animal Sciences, Central University of Himachal Pradesh Shahpur Campus, Kangra 176206, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pesticides are widely used to control pests, but their widespread use raises concerns regarding potential health risks for humans. There are several routes through which pesticides can be ingested, inhaled, and absorbed, resulting in acute and long-term health consequences. This systematic review synthesizes the available evidence regarding the health risks and long-term effects of pesticide exposure, with a particular focus on epidemiological and toxicological studies. A systematic review was conducted by searching scientific databases i.e. Scopus, and Web of Science for peer-reviewed articles published between 2000 and 2024. Studies were selected based on their focus on pesticide exposure, health risks, and long-term effects. Meta-analysis was conducted where sufficient homogeneity of outcomes allowed. This review identified consistent associations between chronic pesticide exposure and non-communicable diseases, including cancer, neurological disorders, and endocrine disruptions. An increased incidence of respiratory issues and neurodegenerative diseases was often associated with occupational exposure to pesticides. People exposed for a prolonged or high intensity time period, particularly agricultural workers, were more likely to experience long-term health effects. There are a number of factors that influences the ability to draw definitive conclusions, including variations in pesticide types, exposure levels, and health outcomes. Chronic exposure to pesticides presents significant health risks, particularly for individuals in high-exposure environments like agriculture. While evidence indicates strong associations with several long-term health conditions, additional research is necessary to elucidate dose-response relationships and mechanisms of action. This review underscores the necessity for enhanced regulatory measures and improved safety protocols to mitigate pesticide-related health risks.

Indexed as

Health risksLong-term effectsPesticidePesticide regulationSafety protocols

Identifiers

PMID39717852
PMCPMC11664077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.