ArticleAsia-Pacific journal of oncology nursing2025
Relationship between severe radiodermatitis and skin barrier functions in patients with head and neck cancer: A prospective observational study.
Article in Asia-Pacific journal of oncology nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Evidence summary on non-pharmacological interventions of the radiation dermatitis in patients with head and neck cancer.Asia-Pacific journal of oncology nursing · 2026Review
- Risk factors for severe radiation-induced dermatitis in nasopharyngeal carcinoma patients undergoing radiotherapy.Frontiers in oncology · 2026Article
- Oral microbiota: Roles and treatment in radiation injury (Review).Oncology letters · 2025Review
- Skin Microbiome and Radiation-Induced Skin Injury: Unraveling the Relationship, Mechanisms, and Therapeutic Implications.International journal of molecular sciences · 2025Review
- Antimicrobial photodynamic therapy for severe acute radiodermatitis in patients undergoing head and neck radiotherapy: a case series.Frontiers in oncology · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Objective: Severe radiodermatitis with erosion is a painful condition that affects quality of life; therefore, developing methods for its prevention is an urgent issue. Therefore, this study aimed to determine the morphological characteristics of the development and healing processes of severe radiodermatitis in patients with head and neck cancer and to explore the association between skin barrier function and development of severe radiodermatitis. Methods: In this prospective observational study, the cervical regions of patients with head and neck cancer who underwent radiotherapy at a university hospital from October 2022 to March 2023 were photographed, and morphological characteristics of the development and healing process of severe radiodermatitis were extracted using the qualitative sketch method. Skin barrier function, including skin microbiota and dermal echogenicity, was investigated before initiating radiotherapy, and its relationship with radiodermatitis was examined using the Mann-Whitney Results: Nine patients were followed for a median of 61 (range 55-87) days with a total of 88 observations. The morphological characteristics of severe radiodermatitis were "localized erosion-epithelialization" and "widespread erosion-crusting," and compared to non-severe radiodermatitis, with low levels of Conclusions: To prevent severe radiodermatitis, in addition to moisturizing the irradiated area and protecting it from mechanical irritation, improving skin barrier function before radiotherapy initiation may be effective.
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