ReviewHeliyon2024
Impact of hypoxia on alveolar bone dynamics and remodeling.
Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Roxadustat Inhibits Osteoclast Differentiation and Function by Disrupting Cell Cycle Exit.International journal of molecular sciences · 2026Article
- Mechanisms underlying end-organ injury in sleep apnoea.The European respiratory journal · 2026Review
- The Hypoxostat Model: A Conceptual Framework Linking Hypoxia, Oxidative Stress and Periodontal Breakdown Under Orthodontic Load.Antioxidants (Basel, Switzerland) · 2026Article
- The Role of Wnt Signaling in Age-Related Alveolar Bone Loss and Regeneration.Journal of periodontal research · 2026Review
- Exosomes as Precise Regulators of the Osteoimmune Microenvironment: Engineering Strategies for Bone Regeneration.Biomaterials research · 2026Review
- Hypobaric hypoxia aggravates neuroinflammation in ligature-induced periodontitis mice via the STAT3 signaling pathway.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxygen is a fundamental requirement for cellular metabolism. Hypoxia is a state of oxygen deprivation of the tissues. Cells develop numerous adaptive mechanisms to survive hypoxic insult. Alveolar bone is a unique structure that encases and protects the tooth. Literature reports that hypoxia, in all forms, impacts alveolar bone health. The hypoxia-inducible pathway appears to play a key role in mediating changes in alveolar bone metabolism. Embryonic hypoxia plays a vital role in craniofacial skeletal development. Further, hypoxia has been anticipated in the repair of extraction sockets. Alveolar bone cells respond distinctly to hypoxic conditions with both beneficial and detrimental effects. Studies have demonstrated enhanced alveolar bone resorption upon hypoxic stimuli. However, hypoxia has also been shown to have potential therapeutic effects on alveolar bone by triggering an angiogenic response. Additionally, the type, duration, and mode of hypoxia are critical in triggering varied responses in alveolar bone metabolism. The main objective of this review is to recapitulate the effects of different types of hypoxia on the tooth supporting apparatus and to analyze some of the presumptive mechanisms underlying hypoxia-induced changes in alveolar bone remodeling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.