ArticleOsteoarthritis and cartilage open2025
The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain.
Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Dose-dependent histopathological and immunohistochemical effects of metformin in experimental osteoarthritis.Clinical rheumatology · 2026Article
- Therapeutic effects of teriparatide on subchondral bone lesions and pain in mono-iodoacetate-induced osteoarthritis rat model.Osteoarthritis and cartilage open · 2025Article
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9 authors.
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Abstract
Objectives: Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (OA). We identified and developed a method for scoring comparable pathology in two rat OA knee pain models. Methods: Rats (n = 8-10 per group) were injected with monoiodoacetate (MIA) or saline, or underwent meniscal transection (MNX) or sham surgery. Pain behaviour (weight bearing asymmetry and mechanical hindpaw withdrawal thresholds (PWTs)) were measured and knee samples obtained. Features associated with BMLs were evaluated using haematoxylin and eosin or Safranin-O stained knee sections. Sections were scored for chondropathy, osteophytes, synovitis and with the human OA Bone Score modified for rats (rOABS). rOABS reliability was assessed with intraclass correlation coefficient (ICC), groups were compared using Mann-Whitney U-tests, and associations examined with Spearman's rho. Results: OABS features were more prevalent in each OA pain group than in controls. rOABS displayed good inter-rater reliability (ICC = 0.79). rOABS was higher in each model than controls; MIA 3.0 (2.3-4.0) vs vehicle 0.0 (0.0-0.0), and MNX 4.0 (2.3-4.8) vs sham 0.0 (0.0-0.0), each p < 0.003. rOABS was associated with OA cartilage involvement (rho = 0.69, p < 0.001), osteophyte (rho = 0.61, p < 0.001) and synovial inflammation (rho = 0.76, p < 0.001). Higher rOABS was associated with pain behaviour: weight bearing asymmetry (rho = 0.65, p < 0.001) and PWT (rho = -0.47, p = 0.003). Conclusions: Subchondral pathology in rat OA models resembles human subchondral BMLs. rOABS reliably measured subchondral pathology and was associated with OA structure and pain behaviour.
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