Evidence map›Paper›PMID 39717487›Full record

ArticleFrontiers in aging2024

Heightened cholesterol 25-hydroxylase expression in aged lung during

David G Thomas, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado

Abstract read
In one paragraph

Article in Frontiers in aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David G ThomasDepartment of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, United States.
Jianjun YangDepartment of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, United States.
Soo Jung ChoDepartment of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, United States.
Heather Stout-DelgadoDepartment of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, NY, United States.

Funding

Multidisciplinary Approach Training in Respiratory ResearchT32HL134629 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert J Kaner, Heather Winona Stout Delgado · 2018 to 2026
$5.2M
Impact of Heightened UPR Activation on Inflammasome Responses to Influenza and Secondary Streptococcus pneumoniae Infection in Aged LungR01AG056699 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI STOUT DELGADO, HEATHER WINONA · 2018 to 2022
$2.6M
Impact of Aging on Oxysterol Regulation of Alveolar Macrophage Function during S. pneumoniaeR01AG079937 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Heather Winona Stout Delgado · 2023 to 2026
$2.6M
Impact of Heightened ER Stress on NLRP3 Activation in Aged Lung during InfectionR01AG052530 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI STOUT DELGADO, HEATHER WINONA · 2017 to 2021
$2.1M
GLUT1-dependent glycolysis regulates age-susceptible lung fibrosisK08HL138285 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHO, SOO JUNG · 2017 to 2021
$829k
NHLBI NIH HHS K08 HL138285NHLBI NIH HHS T32 HL134629NIA NIH HHS R01 AG052530NIA NIH HHS R01 AG056699NIA NIH HHS R01 AG079937
6 · The paper itself

Abstract

Introduction: Alveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to Methods: To observe the impact of aging on Ch25h expression Results: At baseline and in response to infection, cholesterol metabolism significantly altered in aged AM, which corresponded with increased lipid droplet formation. Discussion: The results of our current study demonstrate that Ch25h plays an essential role in modulating aged AM responses to

Indexed as

agingCH25Hcholesterollipid metabolismmacrophageStreptococcus pneumoniae

Identifiers

PMID39717487
PMCPMC11663934

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.