Evidence map›Paper›PMID 39717107›Full record

Trial reportFrontiers in endocrinology2024

Influence of renal function on blood pressure control and outcome in thrombolyzed patients after acute ischemic stroke:

Xinwen Ren, Chen Chen, Xia Wang, Qiang Li, Yang Zhao, Shoujiang You, Menglu Ouyang, Thompson Robinson, Richard I Lindley, Hisatomi Arima and 4 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinwen RenThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Chen ChenThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Xia WangThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Qiang LiThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Yang ZhaoThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Shoujiang YouDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of SooChow University, Suzhou, China.
Menglu OuyangThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Thompson RobinsonDepartment of Cardiovascular Sciences and National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, Leicester, United Kingdom.
Richard I LindleyWestmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Hisatomi ArimaThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Xiaoying ChenThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
John ChalmersThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Craig S AndersonThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Lili SongThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The effect of renal impairment in patients who receive intravenous thrombolysis for acute ischemic stroke (AIS) is unclear. We aimed to determine the associations of renal impairment and clinical outcomes and any modification of the effect of intensive versus guideline-recommended blood pressure (BP) control in the BP arm of the International Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Methods: We conducted a Results: Of the 2,151 patients with available baseline renal function data (mean age 66.9 years; 38% women), 993 (46.2%), 822 (38.2%), and 336 (15.6%) had normal (eGFR ≥ 90 mL/min/1.73 m Discussion: The presence of moderate-to-severe renal impairment is associated with increased mortality in thrombolyzed patients with AIS. Renal function does not modify the effect of early intensive BP-lowering treatment on death in this patient group.

Indexed as

Blood PressureGlomerular Filtration RateIschemic StrokeAgedAntihypertensive AgentsFemaleFibrinolytic AgentsHumansHypertensionKidneyMaleMiddle AgedThrombolytic TherapyTreatment OutcomeAntihypertensive AgentsFibrinolytic Agentsacute ischemic strokeblood pressureclinical outcomerenal functionthrombolysis

Identifiers

PMID39717107
PMCPMC11663659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.