Evidence map›Paper›PMID 39717106›Full record

ArticleFrontiers in endocrinology2024

BRAFV600E/pTERT double mutated papillary thyroid cancers exhibit immune gene suppression.

Ana-Maria Sigarteu Chindris, Michael Rivera, Yaohua Ma, Asha Nair, Yi Liu, Xue Wang, Brian M Necela, Jennifer M Kachergus, John D Casler, Christopher Brett and 6 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ana-Maria Sigarteu ChindrisDivision of Endocrinology, Mayo Clinic, Jacksonville, FL, United States.
Michael RiveraDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN, United States.
Yaohua MaDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States.
Asha NairDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States.
Yi LiuDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States.
Xue WangDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States.
Brian M NecelaDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Jennifer M KachergusDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
John D CaslerDepartment of Otorhinolaryngology/Audiology, Mayo Clinic, Jacksonville, FL, United States.
Christopher BrettDepartment of Internal Medicine, Mayo Clinic, Jacksonville, FL, United States.
Ana M Rivas MejiaDivision of Endocrinology, Mayo Clinic, Jacksonville, FL, United States.
Victor J BernetDivision of Endocrinology, Mayo Clinic, Jacksonville, FL, United States.
John A CoplandDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Keith L KnutsonDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
E Aubrey ThompsonDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Robert C SmallridgeDivision of Endocrinology, Mayo Clinic, Jacksonville, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: BRAFV600E mutation (BRAF Methods: The abundance of 770 immune gene transcripts was determined by multiprex capture/detection and digital counting of mRNA transcripts using the NanoString nCounter Results: We identified 40 immune transcripts differentially expressed in BRAF Discussion: To our knowledge this is the first report of a potential link between TERT and the immune microenvironment, offering an explanation for the aggressive nature of BRAF

Indexed as

MutationProto-Oncogene Proteins B-rafTelomeraseThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPromoter Regions, GeneticTumor MicroenvironmentBRAF protein, humanProto-Oncogene Proteins B-rafTelomeraseTERT protein, humanBRAF mutation V600 Eimmune geneslymphocytic infiltrationpapillary thyroid cancer (PTC)TERT promoter mutation (pTERT)

Identifiers

PMID39717106
PMCPMC11663634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.