Evidence map›Paper›PMID 39717080›Full record

ArticleiScience2024

Molecular tag for promoting

Hirokazu Yagi, Rino Yamada, Taiki Saito, Rena Honda, Rio Nakano, Kengo Inutsuka, Seigo Tateo, Hideo Kusano, Kumiko Nishimura, Saeko Yanaka and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hirokazu YagiFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Rino YamadaFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Taiki SaitoFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Rena HondaFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Rio NakanoFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Kengo InutsukaFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Seigo TateoFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Hideo KusanoDepartment of Proteomics, National Cancer Center Research Institute, Tokyo 104-0045 Japan.
Kumiko NishimuraDepartment of Proteomics, National Cancer Center Research Institute, Tokyo 104-0045 Japan.
Saeko YanakaFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Takuro TojimaRIKEN Center for Advanced Photonics, Wako, Saitama 351-0198, Japan.
Akihiko NakanoRIKEN Center for Advanced Photonics, Wako, Saitama 351-0198, Japan.
Jun-Ichi FurukawaInstitute for Glyco-core Research (iGCORE), Nagoya University, Nagoya 464-8601, Japan.
Maho Yagi-UtsumiFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Shungo AdachiDepartment of Proteomics, National Cancer Center Research Institute, Tokyo 104-0045 Japan.
Koichi KatoFaculty and Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MCFD2 and ERGIC-53 form a cargo receptor complex that plays a crucial role in transporting specific glycoproteins, including blood coagulation factor VIII, from the endoplasmic reticulum to the Golgi apparatus. We have demonstrated that MCFD2 recognizes a 10-amino-acid sequence in factor VIII, thereby facilitating its efficient transport. Moreover, the secretion of biopharmaceutical recombinant glycoproteins, such as erythropoietin, can be enhanced by tagging them with this sequence, which we have termed the "passport sequence" (PS). Here, we found that the PS promotes the galactosylation and sialylation of

Indexed as

BiochemistryGlycobiologyMolecular biologyProperties of biomoleculesProtein

Identifiers

PMID39717080
PMCPMC11664129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.