Evidence map›Paper›PMID 39716968›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor-Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy.

Lang Yan, Liang Chang, Yijun Tian, Jinyan Hu, Zhi Cao, Xiang Guo, Bijiang Geng

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Design of a Wobble-Scheme Heterojunction for Catalytic Cancer Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  17. Review
  18. Review
  19. Hollow RuOTheranostics · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lang YanDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Liang ChangDepartment of Emergency and Critical Care, Shanghai Changzheng Hospital, Second Affiliated Hospital, Naval Medical University, Shanghai, 200003, China.
Yijun TianDepartment of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Jinyan HuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Zhi CaoDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Xiang GuoDepartment of Orthopaedics, Shanghai Changzheng Hospital, Second Affiliated Hospital, Naval Medical University, Shanghai, 200003, China.
Bijiang GengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.ORCID https://orcid.org/0000-0003-4819-2577

Funding

National Natural Science Foundation of China 22108168National Natural Science Foundation of China 82173649National Natural Science Foundation of China 82272454Naval Medical University Youth Start-Up Fund 2023QN011Outstanding Young Medical Talents Program of Shanghai Municipal Health Commission-Outstanding Project 20234Z0016Young Elite Scientists Sponsorship Program by CAST 2023QNRC001
6 · The paper itself

Abstract

Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, the non-tumor-specific release of Cu ions can induce cuproptosis and cause irreversible damage to normal tissues. To maximize the therapeutic effects of tumor-specific cuproptosis, this work reports for the first time the regulation of degradation behaviors of Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer. The deposition of GQDs not only avoids the degradation of Cu

Indexed as

CopperGraphiteImmunotherapyNeoplasmsQuantum DotsAnimalsCell Line, TumorHumansMiceReactive Oxygen SpeciesTumor MicroenvironmentUltrasonic TherapyCopperGraphiteReactive Oxygen SpeciesCu2O nanocubesgraphene quantum dotsimmunotherapysonodynamic therapytumor‐specific cuproptosis

Identifiers

PMID39716968
PMCPMC11831527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.