Evidence map›Paper›PMID 39716938›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Multidimensional Proteomic Landscape Reveals Distinct Activated Pathways Between Human Brain Tumors.

Shuang Yang, Yongtao Zheng, Chengbin Zhou, Jun Yao, Guoquan Yan, Chengpin Shen, Siyuan Kong, Yueting Xiong, Qingfang Sun, Yuhao Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shuang YangInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200241, P. R. China.
Yongtao ZhengInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200241, P. R. China.
Chengbin ZhouDepartment of Neurosurgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, P. R. China.
Jun YaoInstitutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.
Guoquan YanInstitutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.
Chengpin ShenShanghai Omicsolution Co., Ltd., Shanghai, 200000, P. R. China.
Siyuan KongInstitutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.
Yueting XiongInstitutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.
Qingfang SunDepartment of Neurosurgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, P. R. China.
Yuhao SunInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200241, P. R. China.
Huali ShenInstitutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.
Liuguan BianInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200241, P. R. China.
Kun QianInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200241, P. R. China.
Xiaohui LiuInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200241, P. R. China.ORCID https://orcid.org/0000-0002-7728-7121

Funding

Fundamental Research Funds for the Central Universities YG2024QNB04Medical-Engineering Joint Funds of Shanghai Jiao Tong University YG2021ZD09National Key R&D Program of China 2021YFA1301601National Key R&D Program of China 2021YFF0703500National Key R&D Program of China 2022YFE0103500National Natural Science Foundation of China 81827901National Natural Science Foundation of China 81971771National Natural Science Foundation of China 82001261National Natural Science Foundation of China 82272174National Research Center for Translational Medicine at Shanghai NRCTM(SH)-2023-02Science and Technology Innovation Action Plan of STCSM 22S31901900Shanghai Commission of Science and Technology 20Z11900103Shanghai Jiao Tong University Inner Mongolia Research Institute 2023YFE0108800Shanghai Science and Technology Plan Funds 22142202400Shanghai Science and Technology Plan Funds 22DZ2291700
6 · The paper itself

Abstract

Brain metastases (BrMs) and gliomas are two typical human brain tumors with high incidence of mortalities and distinct clinical challenges, yet the understanding of these two types of tumors remains incomplete. Here, a multidimensional proteomic landscape of BrMs and gliomas to infer tumor-specific molecular pathophysiology at both tissue and plasma levels is presented. Tissue sample analysis reveals both shared and distinct characteristics of brain tumors, highlighting significant disparities between BrMs and gliomas with differentially activated upstream pathways of the PI3K-Akt signaling pathway that have been scarcely discussed previously. Novel proteins and phosphosites such as NSUN2, TM9SF3, and PRKCG_S330 are also detected, exhibiting a high correlation with reported clinical traits, which may serve as potential immunohistochemistry (IHC) biomarkers. Moreover, tumor-specific altered phosphosites and glycosites on FN1 are highlighted as potential therapeutic targets. Further validation of 110 potential noninvasive biomarkers yields three biomarker panels comprising a total of 19 biomarkers (including DES, VWF, and COL1A1) for accurate discrimination of two types of brain tumors and normal controls. In summary, this is a full-scale dataset of two typical human brain tumors, which serves as a valuable resource for advancing precision medicine in cancer patients through targeted therapy and immunotherapy.

Indexed as

Biomarkers, TumorBrain NeoplasmsGliomaProteomicsFemaleHumansMaleProteomeSignal TransductionBiomarkers, TumorProteomebiomarkersbrain metastasesgliomasmass spectrometrymultidimensional proteomics

Identifiers

PMID39716938
PMCPMC11831486

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.